X. He

The paper presents cryo-EM structures of the ghrelin receptor bound to ghrelin and GHRP-6, revealing the binding pocket for the octanoyl group and providing insights for drug design.

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

This study shows that non-neutralizing antibodies targeting HIV-1 envelope regions reduce mucosal infection and virus burden in humanized mice through Fc-mediated effector functions.

The paper shows that in a glacier forefield, community assembly shifts from dispersal-dominated to niche-based processes after 60 years of succession, supported by declining multi-beta-diversity.

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

This study investigates how EPAC1 regulates rickettsial adhesion to endothelial cells by modulating ANXA2 Y23 phosphorylation, using in vivo models and FluidFM.

The paper shows rapid but limited adaptation in copepod populations to combined ocean warming and acidification over 25 generations.

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

This study investigates the evolutionary mechanisms of sexual systems in liverworts, showing dioicy is ancestral and more stable than monoicy, driven by genetic and environmental factors.

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

This study shows that low doses of Ad26.COV2.S vaccine protect rhesus macaques against SARS-CoV-2 challenge, with higher doses needed for upper respiratory tract protection.

The paper analyzes single-cell transcriptomes during liver transplantation to understand ischemia-reperfusion injury and identifies a protective role for TNIP3 in Kupffer cells.

This study designs a de novo regulation system using TFs and CREs to alter plant secondary metabolism, showing reduced tobacco alkaloids and nitrosamines in engineered plants.

The paper develops a non-infectious SARS-CoV-2 replicon system to study viral replication and test antiviral compounds, revealing cell-line-specific inhibitor potencies.

The paper develops a method to measure subnanometer position changes of biomolecules in live cell plasma membranes using extracellular quenchers and validates it by studying peptide-induced membrane perforation.

The paper identifies cis-regulatory changes in a gene linked to adaptive radiation in cichlid fishes by showing their impact on gene expression patterns across lineages.

The paper maps root-microbe interactions in Arabidopsis thaliana by identifying host genetic variants and microbial hubs that influence microbial network structures and functions.

This study uses a Drosophila larval model to show that ROS-dependent innate immune mechanisms control S. aureus MRSA virulence by modulating H2O2 production and antimicrobial peptide responses.

This study examines how smart glass affects stomatal sensitivity in Capsicum plants by altering light conditions, finding that light intensity is more critical than spectral quality for stomatal responses.

This study identifies TaGS1.1 as critical for nitrogen assimilation and spike development in wheat by analyzing CRISPR-edited mutants and their growth responses under varying nitrogen conditions.

The paper identifies microbial markers for early colorectal cancer detection across populations using meta-analysis and classifier models, achieving high diagnostic accuracy.

This study identifies gene expression changes and pathways involved in passion fruit ripening and senescence using RNA sequencing and validates findings with RT-qPCR.

This study analyzes S:A ratios across species to understand dosage compensation mechanisms in sex chromosomes, finding clade-specific patterns and supporting the sex chromosome insensitivity hypothesis.

This study captures novel genomes from Saccharibacteria groups in humans and mammals, revealing convergent evolution and independent adaptation to human hosts.

The paper links species traits to extinction risk across diverse taxa, identifying key traits that predict vulnerability to extinction globally.

This study shows that exogenous melatonin administration restores diurnal rhythms in gut microbiota and host metabolism in high fat diet-fed mice.

This paper develops a computer-aided method to assess growth ring boundaries in softwood using image processing, achieving 98% accuracy by analyzing 100 micro-images.

The paper compares tumor and normal single-cell mRNA data to show neuroblastoma cells resemble fetal sympathoblasts across diverse samples.

This paper develops a laser-activated drug implant for controlled release in the posterior eye, showing in vitro and in vivo drug release kinetics and safety.

This study shows that loss of Aldob activates Akt, promoting hepatocellular carcinoma by destabilizing the Aldob/Akt/PP2A complex, and identifies SMAP as a potential therapeutic agent.