X. Wang

The paper quantifies natural selection across the Norway spruce genome, finding strong regulatory selection and effects of Hill-Robertson interference on adaptation.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This paper introduces hydrazine-based chemoproteomic probes to target cofactor-dependent enzymes, enabling enzyme discovery and drug development through diverse functional profiling.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This paper identifies and profiles bisecting N-acetylglucosamine modifications in human amniotic membrane through glycomic and glycoproteomic analyses, revealing 41 glycoproteins with this modification.

This study identifies lipid differences in plasma, microvesicles, and exosomes between preterm and full-term pregnancies, finding microvesicle lipids better predict preterm birth risk.

This study shows that a soluble high-fibre diet enhances radiosensitivity of bladder cancer xenografts in mice, associated with increased Bacteroides acidifaciens abundance and microbial metabolites.

This paper identifies DXR as a druggable target for zoonotic staphylococci and develops potent prodrug inhibitors (MEPicides) that bypass transporter requirements.

The paper identifies monocyte subsets with high osteoclastogenic potential and shows IRF8 regulates their epigenetic and transcriptional programs.

This study identifies integrin β3 as a RACK1-interacting protein essential for PRRSV infection and NF-κB activation in Marc-145 cells, revealing a positive feedback loop involving NF-κB and ITGB3/RACK1.

The paper identifies DNase activity in invadosomes across cell types and species, revealing DNase X as the recruited enzyme that degrades extracellular DNA.

The paper identifies EB1 as an interacting partner of PTPN22 and shows that this interaction regulates T cell receptor signaling by modulating EB1 phosphorylation and downstream signaling molecules.

The paper shows that the non-signaling complex formed by Activin A and ACVR1 reduces disease severity in FOP by tempering heterotopic ossification.

This paper describes the design of a fusion protein using human ferritin to present the SARS-CoV-2 spike glycoprotein RBM, suggesting it as a potential vaccine candidate.

This study develops a thermostable anti-EBOV IgY antibody that retains neutralizing activity for one year at 25°C and provides complete protection in a mouse model.

This study reports Cryo-EM structures of GltPh to elucidate domain movements and their role in substrate release and inhibition.

This study compares the binding of SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins to glycans, finding HS binding is sulfation-dependent and sialic acid binding is absent.

This study develops a SARS-CoV-2 vaccine candidate using virus simulating particles that induces strong neutralizing immune responses with a single dose.

The paper introduces an iSUF platform to enrich and purify tumor-derived extracellular vesicles from biofluids, showing high enrichment and biomarker expression in clinical samples.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

The paper introduces 2D-HELS-AA MS Seq to directly sequence tRNA, revealing different isoforms and dynamic base modifications.

This study shows that Nelfinavir inhibits DDI2, blocking NFE2L1 proteolysis and enhancing the effectiveness of proteasome inhibitors in cancer treatment.

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

This study reveals hidden research bias in urothelial carcinoma cell lines due to driver gene loss from random mutation, suggesting next-generation sequencing is needed and conditionally reprogrammed cells may be a better alternative.

This study uses molecular dynamics simulations to show that Remdesivir's 1-cyano group inhibits SARS-CoV-2 RdRp by disrupting nucleotide addition and proofreading, providing insights for drug design.

This study establishes a BRBV replicon system and identifies myricetin as a potent inhibitor of BRBV replication with a high therapeutic index.

This study shows that STAT2 signaling both restricts SARS-CoV-2 spread and causes severe pneumonia in infected hamsters.

The paper determines the near-atomic structure of the SARS-CoV-2 polymerase complex and shows reduced activity and thermostability compared to SARS-CoV.