X. Xu

The paper develops a D-2-hydroxyglutarate biosensor using DhdR, which detects D-2-HG in biological samples with high specificity and sensitivity.

This study identifies ginsenoside Rg3 as a molecular glue that enhances mitochondrial UPR via the TRKA-GRB2-EVI1-CRLS1 axis to restore proteostasis in Parkinson's disease.

The paper explains leaf economics using optimality principles, showing how leaf lifespan and LMA relate to environmental factors and resolving discrepancies in plant traits.

This study identifies MTHFD2 as a metabolic checkpoint that regulates T cell fate and function by promoting effector cells and suppressing regulatory T cells.

This study identifies a novel folliculogenesis and follicular placentation mechanism in black rockfish, highlighting hormonal changes and conserved genes in placental development.

This paper develops a stable transformation technique for the hornwort Anthoceros agrestis using Agrobacterium, enabling genetic studies of molecular mechanisms in land plants.

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study shows that GPCR-mediated PLCγ2 activation drives neutrophil dysregulation in cold-induced urticaria in PLAID patients.

The paper identifies cellular senescence and TGF-beta pathways in HIV-infected individuals that contribute to HIV latency and poor immune recovery, suggesting potential therapeutic targets.

The paper uses genomic data to classify the Chinese mountain cat as a wildcat subspecies and finds no evidence of its role in domestic cat domestication in East Asia.

This study uses micro-XRF to analyze the holotype of Jianianhualong tengi, revealing elemental patterns linked to fossil structure and taphonomy.

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

The paper examines how plot diversity affects the metabolome of leaves, roots, and root exudates in four subtropical tree species, finding stronger effects on leaves than roots or exudates.

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

The paper reports cryoEM structures of DNA-PKcs in inactive and activated forms, revealing structural changes in HEAT repeats that drive kinase activation.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study identifies two efficient multiplex genome editing tools for Phalaenopsis orchids using a protoplast platform, with DPII-Cpf1 showing the highest editing efficiency.

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

This study examines life-history fitness in F1 hybrids of Daphnia pulex and D. pulicaria, finding heterosis in four out of five traits, suggesting no major genetic incompatibilities and early speciation stage.

The paper measures nuclear stiffness in native tissues and finds that matrix disruption reduces both tissue and nuclear stiffness.

This paper introduces a method using high-pressure NMR spectroscopy to identify proteins with internal ligand-binding voids by detecting nonlinear chemical shift changes in 1H/15N HSQC experiments.

The paper shows that Cdc42 activity is crucial for the interaction between the cAMP/PKA pathway and CatSper function in sperm, affecting Ca2+ transport and fertilization.

The paper uses all-atom simulations to study protein condensates, revealing structural and dynamic details of phase separation in two IDPs and showing agreement with experiments.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

The paper uses high-pressure NMR to study conformational changes in ARNT PAS-B Y456T, finding that the slipped conformation is smaller and less compressible than the wildtype and involves an unfolded intermediate.

The study tracks vagino-cervical microbiome changes in 60 women over a year after oral probiotics, finding no colonization but stability in Lactobacillus-dominated communities and potential benefits for some individuals.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.