X. Xu

This study develops a novel preclinical model to assess long-term effects of precision radiation on salivary function and tissue integrity in mice.

The paper shows HetL provides immunity to HetR against PatS inhibition, enabling heterocyst differentiation in Nostoc PCC 7120 under nitrogen starvation.

This study identifies that BTLA and PD-1 use distinct phosphatases to differentially repress T cell signaling, highlighting mechanistic differences between two co-inhibitory receptors.

This paper develops a CRISPR-based DNA detection method (CADD) that rapidly and specifically detects DNA from bacteria, cancer cells, and viruses in 30 minutes at room temperature.

The paper identifies and analyzes MATE transporter genes in wild chickpea species under aluminum stress, finding that CaMATE2 is upregulated in all lines while CaMATE1 is upregulated in most, correlating with root growth responses.

The paper uses a two-step molecular approach to delimit species in the spider genus Heptathela, identifying 20 putative species from 180 sampled individuals.

This study shows that CAPRI enables human neutrophils to chemotax through a broader range of chemoattractant gradients by controlling Ras adaptation and sensitivity.

This study shows that Salmonella Enteritidis effector AvrA suppresses autophagy by reducing Beclin-1 protein via the JNK pathway, promoting bacterial survival in host cells.

The paper uses phylogenetic analysis and ancestral state reconstruction to estimate flight potential in early birds and their relatives, finding that powered flight potential emerged multiple times from ancestors with high potential.

The paper investigates how HetR controls gene expression from DIF1 motif promoters during heterocyst differentiation, showing dependence on HetZ and modulation by PatU3.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.

The paper identifies RASSF proteins as effectors linking RAS GTPases to the Hippo pathway, showing specificity in binding and regulatory roles.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.

This study shows that MAPK-induced miR-29 suppresses melanoma by targeting MAFG, and its inactivation accelerates tumor development.

Two Arabidopsis mutants in the strigolactone pathway show delayed sepal senescence, with transcriptional analysis revealing interaction between strigolactones and sugar signaling.

This study identifies acetylation as essential for NLRP3 inflammasome activation, showing that KAT5-mediated acetylation promotes NLRP3 aggregation and inflammasome assembly.

This study identifies RpvA, a LysR-type regulator in S. aureus, which controls persister formation and virulence by modulating metabolism and virulence gene expression.

This study designs core-porous shell upconversion nanoparticles to enhance both fluorescent and MRI signals for dual-modal biomedical imaging.

This paper determines the atomic structures of the C. difficile binary toxin CDTb using cryoEM and X-ray crystallography, revealing novel di-heptamer forms and critical domains for toxicity and stability.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

This paper develops an ESC-based melanoma mouse model platform to rapidly generate genetically engineered mice for melanoma research using multiple genetic strategies.

This study investigates sex chromosome evolution in paleognath birds, finding that tinamous have higher substitution rates and unique evolutionary strata without chromosomal inversion.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.