Y. Gao

The paper presents a structural model of an Alzheimer's Aβ42 oligomer based on solid-state NMR and cryo-EM data, explaining its stability and ion permeability.

This study reports chromosome-level genome sequences of two Leonurus species, providing resources for studying bioactive molecules in medicinal plants.

This paper introduces an Odourgenetic method using Drosophila odorant receptors to non-invasively and rapidly manipulate cellular functions and behavior through inhalation of 2-pentanone.

This study uses urine proteomics to analyze the effects of e-cigarettes on rats, identifying differential proteins and pathways linked to immune, cardiovascular, and respiratory systems.

The paper uses urine proteomics to detect startle-induced changes in rats, identifying differential proteins related to neurotransmitter and glucose transport.

The paper establishes a stable human cell line as a reference for transcriptomic and proteomic studies, showing consistent results across generations and platforms.

This study shows that AHR activation by dietary ligands improves gut barrier function via zinc-dependent pathways, highlighting the role of zinc in AHR signaling and its protective effects against IBD.

The paper presents a chromosome-level genome assembly of T. grandis and identifies genes responsible for gymnosperm-specific sciadonic acid biosynthesis.

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

This study identifies Naproxen as a chemical inhibitor of PIN auxin transporters in plants, revealing its mechanism of action through cellular, biochemical, and structural analyses.

This study examines how HE4 contributes to hyperoxia-induced alveolar damage in rats by activating ERK and p65, modulating MMP9 and TIMP1 pathways, and promoting fibrosis.

This study investigates how DNA polymerase η extends ribonucleotide-terminated primers, showing reduced fidelity and structural changes during extension.

The paper introduces contact stiffness as a framework to quantify how ECM mechanics influence cell behaviors, showing its correlation with YAP activity and stem cell differentiation.

This study uses urinary proteomics in ApoE-/- mice to identify early biomarkers of atherosclerosis by comparing high-fat diet-induced changes with control groups.

This study identifies a Golgi-dependent pathway involving Arf1 and Sec71 that regulates microtubule growth and reactivates quiescent neural stem cells in Drosophila.

This study uses cryo-EM and HS-AFM to determine the structure of Twinkle helicase and reveals its DNA capture and translocation mechanism, highlighting disease-related mutations and stochastic ATP hydrolysis.

This study shows that BA.4.6, BA.4.7, and BA.5.9 subvariants with R346 mutations evade humoral immunity more effectively than BA.4/BA.5, reducing neutralization titers by 1.5-2.6-fold.

This study examines tRNA transcriptomes and translatomes in mouse tissues to explore their relationship with translational efficiency and tissue-specific proteomes.

The paper uses 13C-tracing to study plant uptake of exometabolites across multiple species, finding that uptake accounts for 23% of the carbon budget in Brachypodium distachyon and that some metabolites promote root growth.

The paper develops an automated container-less cell processing platform using acoustic levitation to improve single-cell proteomics throughput and reproducibility by minimizing sample loss and reducing manual steps.

This study shows that osteocyte ablation in mice leads to senescence-associated changes in bone and bone marrow lineages, causing sarcopenia, osteoporosis, and shortened lifespan.

This study identifies NCgl0254 and NCgl0255 as novel O_SCPLOWLC_SCPLOW-serine exporters in C. glutamicum and shows that all four exporters (ThrE, SerE, NCgl0254, NCgl0255) are interdependent in O_SCPLOWLC_SCPLOW-serine export, with SerE being the major contributor.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

This study analyzes genomic diversity in Asian white birch to identify signals of adaptation and hybridization, finding 7,609 SNPs associated with environmental variables and highlighting climate change risks.

This paper develops a lightweight deep learning model to automatically identify chicken distress calls, achieving high accuracy with reduced computational requirements.

This paper uses molecular dynamics simulations to study the role of PIM lipids in the structure and organization of the Mycobacterial plasma membrane and validates findings with drug testing.

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

This study compares urine proteomes of tumor-bearing mice with those of tumor-resected mice to assess resection completeness.

This paper uses ICA to modularize the TRN of S. aureus USA300 and combines it with a metabolic model to show coordination between CcpA and CodY in regulating carbon and amino acid metabolism.

This study tracks white matter changes in SIV-infected rhesus monkeys with and without cART, finding early alterations at 4 weeks and varying cART effects over time.