Y. Shen

This study identifies macroH2A2 as a regulator of chromatin accessibility at enhancers in glioblastoma, showing that inhibiting Menin increases macroH2A2 and represses self-renewal.

This study shows archaeal extracellular vesicles, produced via ESCRT machinery, transfer DNA and support nutrient cycling in extreme environments.

This paper identifies interfacial compatibility conflict as the cause of poor dentin bonding durability and shows that hydrophobizing the demineralized dentin matrix enhances adhesive infiltration and bonding strength.

The paper identifies a human accelerated region (HAR) that functions as a Leydig cell enhancer for Gli2, affecting male-typical behavior in mice.

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

This study reports cryo-EM structures of CALHM1 channels and proposes a mechanism for ATP permeation through dynamic N-helix movement.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

This study develops a high-throughput method using near-infrared spectroscopy to assess sugarcane stalk quality, achieving high prediction accuracy with RPD values up to 6.3.

This study constructs a liquid-liquid phase separation system through a gel-sol transition of elongated protein microgels in a crowding agent, enabling tunable and monitorable models for drug release applications.

This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.

The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.

The paper evaluates the k-Seq method for measuring ribozyme kinetics, identifying factors affecting accuracy and proposing guidelines to improve data quality.

This study identifies YngB as a UGPase in B. subtilis that contributes to WTA glucosylation and glycolipid formation under anaerobic conditions.

The paper introduces PEAQ biosensing, a method using photochromic single-fluorophore biosensors to measure absolute analyte concentrations or activities in live cells.

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

This paper introduces a simplified agarose microbead-based SiMPull method that is faster, easier, and more reproducible than the original technique while maintaining similar sensitivity and signal-to-noise ratio.

This study examines how healthy aging affects right ventricular structure and biomechanical properties in rats, finding increased peak pressures, wall thickness, and fiber reorientation.

This study identifies T-bet deficiency as a cause of mycobacterial disease by impairing IFN-γ production in innate and innate-like adaptive lymphocytes.

The paper develops a spatially explicit community occupancy model using Markov random fields to analyze mesocarnivore distributions in Apostle Islands, finding that source-sink dynamics better explain species partitioning than competition.

This study identifies IL-22's role in renal metabolic reprogramming through PFKFB3 to treat kidney injury in animal models.

The paper shows that protein condensates undergo a liquid-to-solid transition under mechanical shear, revealing hydrogen bonding as a key factor.

This study examines SARSr-CoV-2 in Malayan pangolins, showing lung infection, vertical transmission, and immune response similarities to COVID-19 in humans.

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

This study shows immune selection pressure in pancreatic cancer drives myeloid mimicry and immune evasion, which can be counteracted by JAK/STAT pathway inhibition to enhance immunotherapy.

This study introduces PORE-cupine, a method combining structure probing and nanopore sequencing to detect RNA secondary structures, revealing isoform-specific structural differences and their impact on translation efficiency.

The paper describes the atomic-level interaction between a bacteriophage endolysin's CBD500 domain and Listeria cell wall teichoic acid, identifying key epitopes and binding mechanisms.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study uses synchrotron soft X-ray nano-computed tomography to quantitatively image the 3D ultrastructure of intact anammox bacteria and explores their shape adaptation to Fe2+.