Y. Shen

This study reports cryo-EM structures of Omicron subvariant S proteins, revealing conformational differences linked to transmissibility and immune evasion.

This study identifies differential proteins and pathways affected by BF-TK/GCV treatment in gastric cancer cells, showing its anti-metastatic effects through proteomics and functional assays.

This study identifies aCcr1, an archaeal transcription factor, and its viral homologs as regulators of cell cycle progression, showing they control cell division by repressing cdvA expression.

This paper develops a method using chiral derivatization and TIMS-MS to separate and visualize 19 pairs of chiral amino acids in complex biological samples.

This study shows UPF3A is not required for NMD in mouse pluripotent and somatic cells, and may only weakly promote NMD in some tissues.

The paper investigates how phase separation of N-myc affects gene transcription and finds that only a small fraction of N-myc-regulated genes are influenced by this process.

This study shows that exosomes from splenic ischemic preconditioning reduce renal ischemia-reperfusion injury by decreasing inflammation and apoptosis.

The paper develops a FRET pair using mScarlet-derived green fluorescent protein (mWatermelon) and mScarlet-I for biosensors, enhancing FRET efficiency through intramolecular association modulation.

This study identifies Rab38 as a physiological regulator of LRRK2 function in melanocytes, showing it enhances LRRK2 membrane recruitment and substrate phosphorylation.

This study constructs a spatiotemporal MRI atlas of fetal brain development in Chinese fetuses, revealing a central-to-peripheral cortical growth gradient and dynamic structural asymmetry.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

This study investigates the structural and biochemical basis of early FER receptor kinase signaling in Arabidopsis, revealing an active conformation and the role of Tyr phosphorylation in substrate activation.

This study shows TR-57 is effective as a single agent and in combination with venetoclax against CLL cells in vitro, regardless of TP53 aberrations.

This study reveals that vimentin intermediate filaments and F-actin form an interpenetrating network in the cell cortex, enhancing contractile forces and influencing actin dynamics.

The paper identifies a molecular mechanism involving FER, ROP2, and TORC that controls root hair elongation under low temperature and nitrogen deficiency in Arabidopsis thaliana.

This paper engineers RNA viruses with an unnatural amino acid to create adjustable immune responses in mice, demonstrating potential for vaccine development.

This study shows that cGAS-STING signaling in cancer cells promotes drug resistance by responding to cytosolic DNA from chemotherapy, suggesting caution in combining STING agonists with chemotherapy.

This study shows HMGA1a undergoes phase separation in the nucleus, driven by protein-DNA interactions and its disordered C-terminal tail.

This study investigates how single-component protein condensates can transform into multiphase architectures during ageing through non-conservative inter-molecular interactions.

This paper introduces a deep learning method for single-frame super-resolution microscopy, enabling live-cell imaging at nanometer-scale spatial and millisecond temporal resolutions.

The paper describes the development of a genetically encoded fluorescent K+ biosensor, GINKO2, optimized for sensitivity and specificity in vivo across multiple species.

This study quantifies TCA flux in tumors and healthy tissues, finding suppressed ATP production in tumors despite increased glycolysis.

The paper characterizes Sulfolobus islandicus DNA polymerase 2 (Dpo2), showing it extends mismatches and lesions but lacks 3-5 exonuclease activity, suggesting a role in DNA repair.

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

This paper develops photosensitized electrospun nanofibrous filters that capture and inactivate airborne coronaviruses under visible light, achieving 99.2% capture and 98.9% inactivation of MHV-A59.

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

This study reveals the structural mechanism of Tn7 transposon target-site selection using cryo-EM, showing how TnsC distinguishes target DNA and prevents reinsertion.

This study shows that error minimization and specificity in the genetic code could emerge as by-products of prebiotic evolution through ribozyme co-option.

The paper shows that CRISPR enriches cells with p53-related mutations and demonstrates that transient p53 inhibition can suppress this effect.

This paper introduces a CRISPR-based assay to identify drug targets affecting hematopoietic cells by analyzing genotype enrichment in mixed CRISPR populations.