Y. Zhou

This paper introduces DraBot, a dragonfly-inspired soft robot capable of locomotion, sensing, and environmental adaptation using pneumatic and microfluidic logic.

The paper uses a HOXA9-mCherry reporter and CRISPR/Cas9 screens to identify USF1/USF2 as regulators of HOXA9 in MLLr leukemia, showing their role in leukemia cell proliferation.

This study shows that promoters and transcription factors coevolve antagonistically in animals and mutually in plants, leading to different transcriptional network transitions.

This study uses scRNA-seq to analyze 110,745 cells from osteosarcoma tissues, identifying malignant subpopulations and TME components, and shows TIGIT inhibition enhances T-cell cytotoxicity.

This study investigates how microbial interactions in the mosquito gut affect Serratia colonization and blood feeding behavior in Ae. aegypti.

The paper identifies broadly neutralizing antibodies against HBV in elite neutralizers and shows that combinations of bNAbs targeting different epitopes are more effective than single bNAbs.

The paper uses a within-host viral dynamic model to estimate the basic reproductive numbers of SARS-CoV-2 and MERS-CoV using chest radiograph data.

This study uses whole genome sequencing to show that relapsed multiple myeloma exhibits accelerated systemic seeding driven by chemotherapy-induced mutations and clonal expansion of single myeloma cells.

This study identifies sex-specific roles of MDSC subsets in glioblastoma, showing mMDSCs drive growth in males and gMDSCs in females, with potential therapeutic targets.

The paper uses single-cell RNA sequencing to analyze stomatal lineage cell development in Arabidopsis, identifying new marker genes and transcriptional networks.

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.

This study identifies tyrosine phosphorylation of ACLY at Y682 as a regulatory mechanism linked to lipid metabolism and oncogenesis in ALK-positive ALCL.

This study defines the caveolar lipid profile using quantitative lipid mapping and simulations, showing how CAV1 and cavin1 sort distinct lipids and create a unique lipid environment.

This study shows that a diversified learning environment improves active avoidance learning and mitigates stress-induced learning impairments in animals.

This study identifies structural variants in Asian rice and its wild ancestor, finding they are predominantly deleterious and contribute to domestication costs and agronomic trait changes.

This study identifies YSL3-mediated copper transport as critical for fertility, grain yield, and size in Brachypodium, with implications for improving crop production in copper-deficient soils.

The paper identifies the genetic basis of sex determination in grapevines by analyzing phased genomes and finding a novel male-fertility gene.

The paper develops a method to estimate population-specific recombination maps using identity by descent segments, showing improved accuracy in European and African American populations compared to existing maps.

This study develops SSR markers linked to seed storability traits in maize by mapping QTL in two populations and identifies four markers with high selection efficiency.

This study identifies a critical role for W571 in HIV-1 Env allostery by showing mutations disrupting CD4-induced rearrangements and rendering Env insensitive to CD4 binding.

The study identifies essential α/β serine hydrolases in P. falciparum as targets of the antimalarial Salinipostin A, which disrupt lipid metabolism and inhibit parasite growth.

This paper introduces a method to classify platelet aggregates by agonist type using convolutional neural networks trained on high-throughput imaging data.

The paper identifies and characterizes lncRNAs in maize, finding that many are derived from transposable elements and play regulatory roles in abiotic stress responses.

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.

This study shows that HMGB1 release in response to mechanical overloading causes inflammation and tendinopathy in mice, which can be blocked by glycyrrhizin.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

This paper identifies the role of TYLCV V2 protein in facilitating the nuclear export of V1 protein and viral systemic infection through host exportin and V1-V2 interaction.

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

The paper develops a method to separate distinct macromolecular structures from heterogeneous cryo-EM data by using common lines in a graphical framework, enabling ab initio 3D structure reconstruction without stringent purification.

This study shows that CD8β+ T cell depletion in SIV-infected macaques does not prevent viral control or protection from challenge, suggesting CD8β+ T cells are not essential for these outcomes.