B. Li

This study develops an OMV-based vaccine using Salmonella Typhimurium to deliver Shigella flexneri 2a O-polysaccharide antigen, showing protection against lethal pulmonary infection in mice.

This study develops a next-generation sequencing-based sterility test (NGSST) that reduces detection time to 48 hours and improves accuracy for biological products.

This study constructs a liquid-liquid phase separation system through a gel-sol transition of elongated protein microgels in a crowding agent, enabling tunable and monitorable models for drug release applications.

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

This study shows mosquito defensin enhances JEV infection by promoting virus adsorption and down-regulating an antiviral protein.

This study shows that evolutionary arms race between bat SARSr-CoV spike proteins and ACE2 drives genetic diversity, with SARSr-CoV spike proteins showing higher binding affinity to human ACE2 than bat ACE2.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

This paper introduces ldSPIM, a method combining light sheet microscopy with nanopipette delivery to precisely deliver single molecules to cells and image their effects in real-time.

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

This paper develops a fluorescent chemodosimeter to visualize and isolate iron-reducing microorganisms at the single-cell level, demonstrating its effectiveness in identifying active FeRM from complex samples.

The paper develops an interpretable machine learning pipeline to predict drug sensitivity in cancer cells using bimodal gene expression patterns from pharmacogenomic data.

This paper introduces a method to determine in situ structures using single particle cryo-EM images without tilt series, improving efficiency and resolution.

This paper improves ELISPOT assay sensitivity for detecting neoantigen-specific T cells by co-stimulating with anti-CD28 and IL-2, increasing detection by up to 5-fold.

This study uses single-cell RNA-seq and TCR sequencing to analyze CMV-reactivated CD4+ T cell subsets, revealing their heterogeneity, functional roles, and interactions.

The paper identifies C53 as a conserved ER-phagy receptor that links autophagy with ribosome-associated quality control during ER stress in plants and mammals.

The paper shows that LOTR1, an extracellular protease, is required for non-cell-autonomous positioning of Casparian Strip domains in plants, coordinating their formation across neighboring cells.

This paper demonstrates a laser-induced cell sorting technique that isolates and cultivates single microbial cells with viability, achieving varying recovery rates across different species.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

This study identifies a rare case where closely related fungi produce structurally distinct beauveriolide analogs, challenging fungal chemotaxonomy and revealing insights into BGC evolution and virulence.

The paper analyzes structural and evolutionary features of cholesterol recognition sites in integral membrane proteins to distinguish specific from nonspecific interactions.

This study develops a network-based immunogenomics model to identify mutations affecting immune responses in cancer and suggests potential immunomodulatory drug candidates.

This study investigates the evolution, cross-species transmission, and origin of bat coronaviruses in China using sequence data and Bayesian analysis.

This study evaluates how different storage conditions, preservation periods, and sequencing platforms affect gut microbiome profiles using 16S rRNA gene sequencing.

This study shows that inhibiting mitochondrial respiration in RPE cells alters intracellular and extracellular metabolites, revealing a metabolic signature of mitochondrial dysfunction.

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

This study shows that CREB1 regulates colorectal cancer cell plasticity by controlling lncRNA CCAT1 and the NF-κB pathway through interactions with CBP/p300 and p65.

The paper uses single-cell RNA sequencing to analyze immature human thymocytes and identifies thymus seeding precursors and T-lineage developmental pathways.

This study examines risperidone-induced DNA methylation changes in first-episode schizophrenia patients and links them to neuroimaging and cognitive phenotypes.

This study identifies recurrent neoantigens in esophageal carcinoma using mutation data from multiple sources, highlighting potential targets for immunotherapy.

The paper constructs an adult human cell atlas from 84,363 cells across 15 organs, identifying 252 cell subtypes and revealing inter- and intra-organ heterogeneity.