H. Jiang

This paper presents full-length transcriptome data of Ascosphaera apis mycelium and spore using PacBio SMRT sequencing, providing high-quality transcripts for genome and transcriptome annotation improvements.

This paper applies federated learning to drug discovery, showing it improves prediction accuracy over centralized training with biased and small datasets.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

This study demonstrates that intracorneal delivery of HSV-1-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis in both animal models and human-derived corneas.

This paper identifies a long non-coding RNA, EDAL, that inhibits neurotropic viruses by promoting EZH2 degradation through O-GlcNAcylation site interference.

The paper introduces a method to predict the functionality of low-frequency missense mutations by integrating mutation counts with relative mutational difficulty, revealing functional p53 mutations and potential cancer prevention strategies.

The paper identifies diverse flanking sequences of blaNDM in specific plasmids from E. coli isolated from poultry, highlighting the role of IS26 in plasmid evolution.

This paper proposes a strategy to select crop varieties based on yield factors and meteorological predictions, showing 70% and 50% success rates in two pilot regions for soybean variety selection.

The paper develops DPY30-targeting peptides that inhibit blood cancer cell growth by disrupting ASH2L binding and H3K4 methylation.

The paper corrects for artifactual post-harvest metabolism in subcellular isotope tracing to reveal compartment-specific metabolic kinetics.

The paper reports that ORF2p expression is undetectable in human cancers despite high ORF1p expression and somatic L1 retrotransposition.

This study identifies TNK2, WASL, and NCK1 as host factors critical for multiple picornavirus infections, showing they function in a common pathway during viral entry.

This study shows that fucosylation of N-glycans modulates Wnt signaling by affecting LRP6 endocytosis, revealing a new glycosylation-dependent regulatory mechanism.

This study shows that p16 suppression increases nucleotide synthesis through mTORC1 activation, promoting tumorigenesis by bypassing senescence.

This paper shows that drh-1 in C. elegans mediates the Intracellular Pathogen Response (IPR) to viral infection, acting as a pattern-recognition receptor independent of its role in RNAi.

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

This study identifies miR-466d-3p as a target of JEV NS3 that regulates IL-1β and viral replication through miRNA degradation.

This study identifies lumbrokinase components using fibrin plate method, fibrin-zymography, and mass spectrometry, revealing fibrinolytic and kinase activities similar to trypsin and plasminogen activators.

This study shows FOP negatively regulates ciliogenesis by promoting cilia disassembly and facilitates cell cycle re-entry.

This study evaluates the effects of Lactobacillus plantarum 15-1 and fructooligosaccharide on broiler chickens challenged with E. coli O78, showing improved intestinal morphology, reduced intestinal injury, and enhanced immune responses.

This study identifies cGAS as a negative regulator of homologous recombination DNA repair, leading to genome instability and cell death.

This paper develops a method to simultaneously quantify and trace dNTP metabolites using isotope dilution and high-resolution mass spectrometry, showing improved accuracy and metabolic pathway insights.

This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.

The paper detects paclitaxel and its metabolites in meconium from newborns exposed to chemotherapy in utero, showing variability in fetal exposure levels.

The paper identifies an artefactual pyruvate formation from lactate during LC-MS analysis, highlighting the need for improved resolution or quantification in metabolomics studies.

This study shows that in situ administration of cytokine combinations can induce complete tumor regression in mice, including large tumors, through strong synergistic effects and systemic antitumor immunity.

This study links field and controlled environment plant height phenotypes in Setaria using genetic analysis, showing height is heritable, polygenic, and influenced by environmental factors and developmental timing.