H. Li

This paper introduces a mouse mammary organoid model that recapitulates lactation and involution processes, enabling study of physiological mammary gland changes and pregnancy-associated breast cancer.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

The paper generates proteomic signatures of kinase inhibitor-induced cardiotoxicity using high-throughput proteomics and integrates them with transcriptomic data to predict drug toxicity.

The paper develops a robust ChIP protocol that significantly improves enrichment fold in birch and Arabidopsis, and is applicable to both woody and herbaceous plants.

The paper characterizes NCR044.1, a plant antifungal peptide, revealing its structure, mechanisms of action, and efficacy against fungal pathogens.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study identifies four clinically used drugs with high binding capacity to SARS-CoV main protease, a potential target for treating 2019-nCoV infection.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

The paper identifies CK2 interacting proteins in M. oryzae and shows CK2 correlates with phosphatases and disaggregases, suggesting a role in protein aggregation and RNA/DNA binding.

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

The paper shows that Dscam isoforms in Chelicerata form cis-multimers and trans-self-bind via Ig1 domains to generate unique homophilic recognition specificities for neuronal self-avoidance.

The paper shows CRIPT enables mitotic spindle disassembly via redox-dependent interactions with tubulin, and mutations disrupt this process.

This paper describes the generation of dual-specific bivalent BiTES for cancer immunotherapy, showing they maintain tumor targeting and kill CEA+ cells in vitro and in vivo.

A vaccine targeting viral protease cleavage sites provides >80% protection against vaginal SIVmac251 infection in macaques by inducing T cell responses and a protective immune environment.

The paper examines insulin signal transduction in the retina of db/db mice, finding impaired signaling marked by increased TNF and IRS-1 phosphorylation and reduced Akt phosphorylation.

The paper investigates how cervicovaginal microbiome composition influences metabolic profiles in healthy pregnancies across trimesters and the first year of life.

This study identifies an insulin-stimulated proteolytic mechanism linking energy expenditure with glucose uptake through TUG cleavage and its nuclear effects.

This study identifies two benzophenanthridine alkaloids from Corydalis longicalcarata rhizomes with anti-mitotic and polyploidy-inducing activities through a phenotypic screen of medicinal plant extracts.

This study examines how hearing sensitivity changes with age in red-eared slider turtles, finding frequency-specific developmental patterns and age-related shifts in auditory thresholds.

This study examines the overwintering behavior and cold hardiness of the purple stem borer in its newly colonized northern range, identifying its survival strategies and potential distribution limits.

The paper identifies MRISC cells as a novel intestinal stem cell niche that produces R-spondin1 via Map3k2 signaling to promote intestinal regeneration after damage.

The paper identifies phosphorylation of H3.3S31 in response to pathogen sensing in macrophages and shows its role in recruiting SETD2 to enhance transcription of inflammatory genes.

The paper evaluates multifaceted diversity traits of microbial groups in biological soil crusts to predict soil multifunctionality, finding that integrating multiple diversity components improves prediction over richness alone.

This study identifies TMEM-131 family proteins as conserved regulators of collagen assembly and secretion across species, showing their role in ER stress and collagen production.

The paper assesses the frequency of deleterious mutations in 21 hereditary breast and ovarian cancer genes among 882 high-risk Chinese individuals, finding 19.5% carried such mutations, with higher rates in those with both breast and ovarian cancer histories.

The paper examines the 3D chromatin structure of mouse female germline stem cells during development, identifying changes in TADs and conserved compartments related to imprinted genes.

The paper was submitted in error and the authors do not wish it to be cited.

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.

This study identifies LncRNA MIR4435-2HG as a mediator of cisplatin resistance in HCT116 cells via the Nrf2/HO-1 pathway.

The paper identifies four humoral immune factors in Biomphalaria glabrata that coordinate to mediate resistance to Schistosoma mansoni infection.