H. Zhou

The paper introduces a method to detect and analyze i6A-modified RNA with single-base resolution using iodine-mediated oxidation and reverse transcription.

This study identifies ZmEREB57 as a maize AP2/ERF transcription factor that enhances salt stress tolerance by regulating OPDA and JA signaling through two distinct pathways.

This study develops synNotch T cells that deliver IFN-gamma to neuroblastoma cells, restoring HLA expression and enhancing T cell-mediated killing without increasing immune checkpoints or systemic IFN-gamma.

This paper identifies a new family of 'Ca. Nanohaloarchaeota' from hypersaline environments, showing they are an intermediate stage in the evolution of symbiosis with Halobacteria.

The paper develops chemical labeling strategies to tag lipid-modified RNAs and identify new regulatory enzymes involved in prenylation.

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

This study identifies endothelial SIRPα signaling as critical for thymic progenitor homing, T cell regeneration, and antitumor immunity through CD47-SIRP interactions and VE-cadherin endocytosis.

The paper determines the in situ atomic structures of VSV components using cryoEM and sub-particle reconstruction, revealing their assembly mechanism through interactions.

This paper identifies 15 genome-wide significant loci for maximum habitual alcohol intake (MaxAlc) in 247,755 U.S. Veterans and shows strong genetic correlations with alcohol use disorder and psychiatric traits.

This study engineers macrophages to inducibly secrete TRAIL in response to the tumor microenvironment, showing improved anti-tumor effects and reduced side effects in preclinical models.

This study shows Streptococcus pneumoniae promotes lung tumorigenesis by activating PI3K/AKT and NF-kB pathways through PspC-PAFR binding in lung cancer cells.

This study identifies a Delta-Omicron recombinant SARS-CoV-2 variant that escapes Sotrovimab neutralization, highlighting the role of recombination in immune escape.

This study shows that breast cancer stem cells escape γδ T cell immunosurveillance by losing key ligands and antigens, and that this escape can be reversed with Zoledronate or IFN- treatment.

This paper introduces VENAS, a system for analyzing SARS-CoV-2 genome evolution networks, enabling rapid processing and visualization of large datasets to trace viral mutations and transmission.

The paper shows that a bacterial E1-E2 fusion protein, Cap2, primes cGAS for antiviral signaling through a process called cGASylation, which increases cGAMP production by ~50-fold.

This study investigates the structural and biochemical basis of early FER receptor kinase signaling in Arabidopsis, revealing an active conformation and the role of Tyr phosphorylation in substrate activation.

The paper presents a cryo-EM structure of α-synuclein fibrils with the A53E mutation, showing structural differences that may affect aggregation kinetics and disease progression.

This study quantifies how anatomical traits of Coffea arabica leaves influence photosynthesis using correlation and path analysis, identifying leaf thickness and stomatal density as key factors.

This study evaluates the neutralization of SARS-CoV-2 Omicron BA.2 by therapeutic monoclonal antibodies, finding reduced neutralization by several antibodies but retention of activity by the AZD8895+AZD1061 cocktail.

The paper determines the structure of the ankyrin complex on human red blood cells and elucidates its assembly mechanism and role in mechanical stability.

The paper shows that actin remodelling facilitates RPAC translation under stress, maintaining proteasome homeostasis in yeast.

This study uses single-cell RNA sequencing to identify five MSC subpopulations, revealing distinct developmental trajectories and functional roles in self-renewal and immunoregulation.

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

The paper isolates and identifies bacterial strains from deep-sea water and sediments in the Mariana Trench, finding that environmental factors shape culturable bacterial diversity.

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

This study evaluates neutralization of SARS-CoV-2 Mu and C.1.2 variants by vaccine-elicited and convalescent antibodies, finding that vaccine-induced responses remain protective despite partial resistance.

The paper assesses Omicron's resistance to vaccine and monoclonal antibody neutralization, finding boosters improve efficacy but existing therapies are largely ineffective.

This study optimizes excitation wavelength and emission window for SPNs to improve imaging quality, showing L1057 NPs achieve superior resolution and signal-to-background ratio in the NIR-IIb window.

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.