K. Xu

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

This study develops a mosaic-type trimeric RBD vaccine that induces strong neutralizing antibodies against Omicron and other SARS-CoV-2 variants in rats.

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

This study identifies a novel immunosuppressive pathway involving Cbl-b-mediated Notch1 degradation and shows that targeting this axis enhances CD8+ T-cell responses and anti-cancer immunity.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

This study investigates the immune evasion and transmissibility of the SARS-CoV-2 Omicron variant, showing significant immune evasion but restored neutralization with booster doses and increased transmissibility due to a more stable spike protein structure.

The paper identifies two distinct ER tubule forms, R1 and R2, regulated by Rtn4 and Climp63, with functional implications for ER structure and dynamics.

This study identifies the gut microbiome-indoleamine 2,3-dioxygenase (IDO1) axis as a mediator of gestational insulin resistance in mice.

The paper measures diffusion coefficients of four enzymes under catalytic conditions and finds no enhanced diffusion.

The paper investigates how asymmetric actin assembly rescues stalled clathrin-mediated endocytosis by analyzing endocytic dynamics and protein geometry using advanced imaging and computational methods.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

The paper identifies a new ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that is essential for autophagosome biogenesis under stress.

This paper introduces a reduced graphene oxide membrane as a supporting film for cryo-EM, improving resolution and particle absorption for sub-100 kDa biomolecules.

This paper introduces excitation spectral microscopy to enable high multiplexing of fluorescent targets in live cells with low crosstalk and high temporal resolution.

This study identifies a tubular ERGIC (t-ERGIC) formed by SURF4 that enhances ER-to-Golgi transport of specific cargoes through unique structural and functional properties.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This paper isolates and characterizes nanobodies from camelids and engineered mice that neutralize SARS-CoV-2 variants through conserved epitopes and multimeric avidity.

This study investigates how the genetic basis of adaptation differs when it occurs through the evolution of selfing modifiers versus mating-unrelated alleles, showing key differences in fixation probabilities and dominance effects.

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

This study shows that glycolysis fuels PI3K signaling in CD8+ T cells, linking metabolic reprogramming to T cell immunity and suggesting therapeutic targets for infectious diseases and cancer.

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.

The paper establishes patient-derived orthotopic xenograft models and cell lines from pediatric high-grade glioma that replicate histopathology, molecular signatures, and drug response, providing a resource for research.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study develops VLP-based vaccines targeting the HIV-1 FP8 epitope, showing they induce high-titer FP8-specific antibodies and effective neutralizing responses in mice.

This study identifies mutations in the Synaptonemal Complex dimerization interface in C. elegans that disrupt chromosome alignment and crossover patterning.

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

The paper uses single-molecule and super-resolution microscopy to map nanoscale diffusional heterogeneities in live mammalian cell membranes, revealing differences in diffusivity across membrane regions and identifying protein crowding as a potential cause.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

This paper introduces PrismNet, a deep learning model that uses in vivo RNA structures to predict protein-RNA interactions and identifies disease-associated mutations affecting these interactions.