L. Chen

The paper introduces NAD+ sensors to measure subcellular and clinical NAD+ dynamics, revealing NAD+ redistribution effects of -GPC in live cells.

This study examines how VRN-1 and PPD-1 alleles affect wheat phenology and yield under autumn and spring sowing conditions.

The paper determines the cryo-EM structure of the SUR1 subunit bound to mitiglinide, revealing its binding site and mechanism of high selectivity.

This study identifies inflammation-induced loss of CFTR-expressing ionocytes in non-eosinophilic asthma using single-cell RNA-seq and confirms it in human and murine models.

This paper describes a scalable method for producing high-quality recombinant three-finger proteins using E. coli, enabling their use as molecular probes.

This study evaluates the impact of R328 mutations on NGLY1 activity using an in vitro assay, identifying dysfunctional, similar, and decreased activity mutations.

This paper estimates gene activation frameworks and system parameters using average transcription level data, revealing distinct regulation scenarios in mouse fibroblast genes.

The paper develops a pipeline to measure exchange rates and concentrations of amide and arginine guanidinium protons in the mouse brain using CEST and validates it with specific mouse models.

This study shows that nitric oxide inhibits gibberellin signaling by S-nitrosylating RGA, balancing growth and salt tolerance in Arabidopsis under salinity stress.

This study uses single-cell RNA sequencing to identify five MSC subpopulations, revealing distinct developmental trajectories and functional roles in self-renewal and immunoregulation.

The paper identifies a new intercellular spread mode of RSV that is virion-independent and antibody-insensitive, contributing to immune escape and viral persistence.

The paper uses GSVA and AI to identify a gene set and immune signals associated with poor prognosis in HBV-related diseases.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

The paper identifies KIR+CD8+ T cells as regulatory cells in humans that suppress pathogenic CD4+ T cells in autoimmune and infectious diseases.

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

The paper presents the cryo-EM structure of the NALCN-FAM155A-UNC79-UNC80 channel complex and elucidates its assembly and regulatory mechanisms.

This paper introduces self-confocal NIR-II fluorescence microscopy systems for in vivo imaging, improving adjustability and enabling cerebrovascular and hepatic imaging.

This study identifies MIG-23 as a key regulator of sperm migration in Ascaris suum by modulating extracellular ATP levels through ecto-ATPase activity.

This study investigates the effect of moxibustion on colorectal cancer liver metastasis using animal models, finding reduced metastasis rates and identifying potential molecular targets.

The paper identifies specific N-terminal processing of beta actin in vivo, showing its impact on actin function and cellular behavior.

This study presents cryo-EM structures of pancreatic KATP channels in closed and pre-open states, revealing nucleotide binding mechanisms and activation by Mg-ADP and diazoxide-type openers.

This study shows that reducing dermal white adipose tissue (dWAT) worsens EGFR inhibitor-induced skin rash in mice, and activating PPARγ with rosiglitazone improves skin function without affecting antitumor effects.

This study uses phylogenomic analysis of Alismatales to investigate adaptations to aquatic environments and identify whole-genome duplication events.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study identifies miR-144 as a regulator of adipogenesis by mediating the formation of the C/EBPα-FoxO1 protein complex, which influences AdipoQ expression and adipocyte differentiation.

The paper develops a causal framework to identify tumor-specific intercellular communication networks in head and neck squamous cell carcinoma, revealing subtype-specific patterns linked to clinical outcomes.

This study tracks immune cell changes in early systemic lupus erythematosus using mass cytometry and identifies longitudinal shifts in Tfh cells and CXCL10.

This study identifies mTOR inhibition as a strategy to overcome RSK3-mediated resistance to BET inhibitors in small cell lung cancer, enhancing apoptosis and antitumor efficacy.

This study identifies two distinct H3 binding modes of NASP and shows how they cooperate to maintain histone H3-H4 homeostasis.