L. Chen

This study shows that HDAC inhibitors butyrate and bufexamac inhibit de novo HIV-1 infection in CD4 T-cells without reactivating latent virus.

This study identifies isoplumbagin as a novel NQO1 substrate that exerts anti-cancer effects by modulating mitochondrial function and dynamics in multiple cancer cell lines.

This study shows that transient hyperglycemia causes long-term vascular endothelial dysfunction and delayed wound healing through DNMT1-mediated Ang-1/NF-κB pathway activation.

The paper determines cryo-EM structures of human TRPC5 channel with two inhibitors, revealing their distinct binding sites and mechanisms of action.

The paper reports structures of Staphylococcus aureus serine hydrolases and their interactions with inhibitors, revealing functional insights and potential targets for therapeutic development.

This study shows that promoters and transcription factors coevolve antagonistically in animals and mutually in plants, leading to different transcriptional network transitions.

This study uses synchrotron soft X-ray nano-computed tomography to quantitatively image the 3D ultrastructure of intact anammox bacteria and explores their shape adaptation to Fe2+.

This study identifies MeSSII's role in cassava starch biosynthesis by forming protein complexes with other enzymes, affecting amylose and amylopectin synthesis.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.

This study shows that PIP3 depletion via PTEN rescues myoblast fusion defects in human rhabdomyosarcoma cells by reducing bubbling blebs during differentiation.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

The paper identifies liver-related signaling pathways activated during RPE EMT using proteomic and phosphoproteomic analysis, suggesting potential therapeutic targets for visual diseases.

This study compares SARS-CoV-2 and SARS-CoV spike-RBD binding to ACE2, showing similar affinities but differing neutralizing antibody cross-reactivity, highlighting challenges for broad-spectrum vaccines.

This paper shows PCNA activates the MutLγ endonuclease to promote meiotic crossing over by facilitating strand-specific cleavage of Holliday junctions.

This paper introduces G-baToN, a reporter system that labels cell-cell interactions through fluorescent protein transfer, enabling study of cancer-stromal cell interactions and other biological processes.

This study shows that myeloid cell mPGES-1 is the main source of PGE2 in inflammatory pain hypersensitivity in mice, suggesting it as a target for new pain therapies.

This study determines the structure of human SOAT1 using cryo-EM and reveals how the inhibitor CI-976 blocks the active site.

The paper identifies a novel glymphatic pathway in the optic nerve for clearing amyloid-beta from the vitreous, which is impaired in glaucoma.

This paper identifies VPS41 mutations causing neurodegenerative disease by disrupting HOPS function and mTORC1 signaling, leading to lysosomal dysfunction and impaired autophagy.

This study identifies Cqs2 as the critical determinant for orchestrating the unisexual cycle in Cryptococcus neoformans without requiring the sex-determination program.

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

The paper develops rm-RGDA to in situ measure nanoparticle size and adlayer thickness, showing it aligns with SEM but differs from DLS and provides insights into protein structure changes based on nanoparticle curvature.

This paper identifies 90 P-gp substrates from 10,804 compounds using a high-throughput screen, including 55 new substrates confirmed by orthogonal assays.

The paper identifies a small molecule cocktail, CEPT, that enhances the viability and cytoprotection of human pluripotent and differentiated cells through multi-target drug combinations.

The paper identifies MRISC cells as a novel intestinal stem cell niche that produces R-spondin1 via Map3k2 signaling to promote intestinal regeneration after damage.

This paper introduces an accelerated SWATH MS method for protein biomarker discovery in FFPE tissues, showing reduced instrument time and batch effects while maintaining good protein quantification and clinical separation.

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.