S. Wang

This study investigates how TGF-β1 and cholesterol interact to influence hepatocyte fate, EMT, and HSC activation in MASLD.

This study identifies humoral immune responses as correlates of protection against Mtb following IV BCG vaccination in rhesus macaques.

This paper develops a porcine model of HFpEF hemodynamics using soft robotic sleeves to test medical devices, showing consistent results with in silico and clinical data.

This study identifies ZBTB48 as a transcription factor that regulates B-cell-specific CIITA expression by binding to its promoter and establishing open chromatin.

This study investigates T. pyogenes-induced damage to bronchiolar epithelium in vitro and in vivo, identifying inflammatory pathways and potential therapeutic targets.

The paper maps 3D genome structures in cancer tissues to identify structural changes and potential biomarkers across cancer progression stages.

This study shows that combining proguanil and chlorhexidine with clarithromycin or rifampicin enhances antibacterial activity against Acinetobacter baumannii in vitro and improves treatment outcomes in mice.

This study identifies BNIP3-mediated mitophagy as a mechanism enhancing lenvatinib-resistant HCC cells' competitive growth through energy metabolism reprogramming.

This study identifies EHBP1 as a protective locus against NASH fibrosis by regulating cholesterol metabolism and interacting with other cholesterol-related genes.

This study develops a ds-GapM-LNA nanobiosensor to visualize lncRNA expression in live hMSCs, revealing MALAT1 dynamics during osteogenic and adipogenic differentiation.

The paper investigates how genomic modifications in phage T4 DNA affect its resistance to nuclease-based defense systems in E. coli, revealing roles beyond simple DNA degradation prevention.

This study uses single-cell spatial transcriptomics and optimal transport analysis to reveal therapy-induced changes in pancreatic cancer microenvironment interactions.

This study uses hypogonadal mice to show sex and reproductive axis effects on intestinal microbial communities, with sex chromosomes also playing a role, and highlights limitations of fecal samples in reflecting small intestine diversity.

This study identifies and characterizes nine genes in the TOR signaling pathway of A. flavus, revealing their roles in growth, aflatoxin biosynthesis, and pathogenicity.

This study characterizes human fetal liver terminal erythropoiesis through RNA sequencing of primary and cultured erythroblasts and immortalized cell lines, revealing gene expression patterns and pathway changes associated with enucleation.

This study shows that combining FAK and PI3K inhibitors synergistically suppresses cervical and pancreatic cancer cell growth by increasing apoptosis and reducing mitosis.

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

This study identifies ENPP1 as an innate immune checkpoint that suppresses the cGAMP-STING pathway, promoting tumor growth and metastasis, and shows that inhibiting its cGAMP hydrolase activity enhances cancer immunity.

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

This study shows that Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance by regulating the Akt-mTOR pathway.

This study examines the microbiota of Amblyomma americanum ticks across different geographic regions and finds that microbiota structure varies between historical and western-expanded populations.

This study visualizes the chaperone-mediated folding trajectory of Gβ5 using cryo-EM, showing how CCT stabilizes intermediates to fold the β-propeller domain.

This study builds an isoform-resolution transcriptomic atlas of colorectal cancer using long-read single-cell sequencing and identifies neoepitopes for vaccine development.

This study uses optogenetic inhibitors to investigate the roles of kinesins-1, -2, -3, and dynein in vesicular transport, revealing their specific contributions to endosome and lysosome motility.

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

This study engineered Yarrowia lipolytica to overproduce nervonic acid through metabolic pathway modifications, achieving high titers and purity.

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

This paper develops an AI algorithm for counting and assessing human pluripotent stem cells in brightfield images, achieving high accuracy and efficiency.

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.