X. Sun

This study identifies SMYD5 as a driver of IBD by downregulating mitochondrial functions through methylation-dependent degradation of PGC-1α in intestinal epithelial cells.

This study investigates the role of YAP1 in TNF-α-induced proliferation and osteogenic differentiation of human periodontal ligament stem cells, finding that YAP1 enhances cell proliferation and differentiation via the Hippo signaling pathway.

This study shows HuR promotes NASH by enhancing DR5/caspase8/caspase3-mediated hepatocyte death through stabilizing DR5 mRNA.

This study shows that a gradient of Dll4 from muscle fibers maintains a continuum of quiescent states in muscle stem cells, preserving their diversity.

This study shows that the C-terminal chromatin-binding domain of Ki-67, along with p53, prevents mitotic chromosome damage in human cells.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study identifies CD36-mediated lipid peroxidation driven by oxidized lipids as a mechanism suppressing anti-tumor CD8 T cell functions in murine tumors.

This study identifies ebselen derivatives as potent inhibitors of SARS-CoV-2 proteases PLpro and Mpro in vitro, with some compounds showing greater potency than ebselen itself.

This study shows PRMT5 promotes cancer metastasis by enhancing EGFR transcription and modulating AKT1 activation through methylation, leading to EMT and tumor cell invasion.

The paper shows that susceptible Pi-ta alleles are retained due to their fitness benefit by acting as an off-switch for immune signaling.

This study compares the DNBSEQ-G400 and Illumina MiSeq platforms for metabarcoding fungal communities, finding DNBSEQ-G400 to be more accurate, less biased, and cost-effective.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This study identifies COUP-TFII as a driver of myofibroblast metabolic shift to aerobic glycolysis, promoting fibrosis in multiple organs.

This study shows UVB light exposure leads to neutrophil migration to the kidney, causing inflammation and injury, with implications for systemic lupus flares.

The paper shows that O- and N-glycans act as signals for Golgi export, affecting the trafficking of transmembrane proteins.

This paper presents a neural model explaining how insects integrate navigational strategies by coordinating different brain regions to process and combine visual cues.

This study presents the genome of Penium margaritaceum, a charophyte alga, to explore evolutionary features leading to land plant colonization and identifies gene expansions and adaptations related to terrestrialization.

The paper identifies the hexosamine biosynthesis pathway as a metabolic vulnerability in KRAS/LKB1 mutant lung cancers and shows GFPT2 inhibition reduces tumor growth.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

The paper profiles SARS-CoV-2 main protease substrate specificity to design activity-based probes for imaging Mpro in patient samples.

The paper identifies LIM domains' direct binding to tensed F-actin as a mechanosensing mechanism, showing force-dependent sequestration affects nuclear localization.

The paper determines the X-ray structure of SARS-CoV-2 main protease and uses it to design alpha-ketoamide inhibitors with improved pharmacokinetic properties.

The paper uses single-cell RNA sequencing to analyze stomatal lineage cell development in Arabidopsis, identifying new marker genes and transcriptional networks.

The rab8d-dependent plastid signal mediated by ATM and GUN1 regulates the root meristem size and renewal of root stem cells, respectively.

This study shows UVB exposure triggers local and systemic Type I interferon responses in mice, which are largely cGAS-dependent and contribute to disease flares in SLE.

This paper develops an endogenous quorum-sensing based CRISPRi circuit (EQCi) to dynamically regulate multiple targets in Streptomyces, achieving higher rapamycin titers without affecting cell growth.

This study shows that SRP-induced compaction of SR and GTPase movements are essential for efficient cotranslational protein translocation at the ER, with implications for disease.

The paper presents the cryo-EM structure of human ACAT1 and reveals its catalytic mechanism and substrate preference for unsaturated acyl chains.

This study develops SSR markers linked to seed storability traits in maize by mapping QTL in two populations and identifies four markers with high selection efficiency.

This study uses mass spectrometry to show that formaldehyde cross-linking in proteins involves two carbon atoms, not one, and identifies new structural insights from cross-links in human cells.