Y. Xiao

This study shows that the nucleocapsid 203 mutation, combined with spike L452R, enhances SARS-CoV-2 immune evasion and fitness, contributing to the dominance of variants like Delta and Omicron.

The paper shows that the retrograde signal MEcPP increases VIR3 abundance, reducing target enzymes and altering plastid metabolism and structure under stress.

The paper describes a self-assessment process to improve lab culture through surveys and group discussions, resulting in a 12% increase in member satisfaction.

This study uses blood vessel organoids from 22q11.2 DS patients to link genetic dysfunction to vascular malformations through single-cell transcriptomics and imaging.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

The paper identifies boundary domain genes tsh1 and lg2 that suppress inflorescence leaf growth and promote branching in maize through regulatory networks and gene duplication events.

This study shows an inactivated multivalent influenza A vaccine provides broad protection against diverse IAV subtypes in mice and ferrets, including non-vaccine strains, suggesting its potential as a universal vaccine.

The paper identifies a genetic interaction between GT1 and RA3 in maize, showing their roles in suppressing carpel development and inflorescence branching through an ancient developmental program.

The paper introduces DeepHoF, a deep learning method to predict viral hosts, and applies it to SARS-CoV-2 to identify potential hosts and analyze host range uniformity during the pandemic.

This study identifies sporadic dissemination of tet(X3) and tet(X6) in livestock-associated Acinetobacter through diverse plasmidomes, highlighting the need for One Health surveillance.

The paper identifies four novel scorpion venom proteins that inhibit Nav1.8, a sodium channel involved in pain signaling, through proteomic and electrophysiological analyses.

This study shows that total body irradiation in mice leads to ovarian cysts and granulosa cell tumors, with effects dependent on age and radiation dose.

This study identifies Reg4 as an antimicrobial peptide that combats Salmonella Typhimurium by binding flagellin and inhibiting bacterial motility, adhesion, and invasion.

This study establishes conditions for dynamic nuclear polarization (DNP) assisted MAS NMR to detect proteins in viable mammalian cells at micromolar concentrations.

This study shows that the N protein mutations R203K/G204R increase SARS-CoV-2 infectivity, replication, and virulence, contributing to its spread and disease severity.

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

This study develops a far-red probe and microfluidic platform to image live erythrocyte membranes at the single-molecule level, enabling high-throughput super-resolution and tracking.

This study shows that MG53 reduces neuromuscular junction loss and extends survival in ALS by protecting diaphragm muscle and NMJ integrity.

The paper analyzes single-cell data from CAR T infusion products to identify factors associated with CD19-positive relapse in ALL patients.

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

This study identifies PAQR3 as a predictor of epirubicin response in TNBC and shows that MAPK inhibition can reverse resistance caused by miR-138-5p-mediated PAQR3 downregulation.

This study shows BRAF inhibitors reprogram cancer-associated fibroblasts to promote matrix remodeling and resistance to therapy in melanoma by enhancing β-catenin signaling and POSTN expression.

The paper shows that Bt-cotton adoption in China increased the prevalence of a symbiotic virus in the cotton bollworm, enhancing its resistance to Bt-cotton.

This study compares three qRT-PCR assays for SARS-CoV-2 detection, finding that CCDC and IPBCAMS N gene assays outperformed WHO assays, while IPBCAMS ORF 1b assay had higher detection rates than others.

The paper investigates how defective interfering genomes affect wild-type poliovirus replication using a mathematical model and experimental data, finding that DI replication and encapsidation are key factors in determining viral competition outcomes.

This study investigates the role of the BMPR-II-SMAD3/MRTF complex in ASMC proliferation and migration in asthma, finding it contributes to airway remodelling.

This study uses electrochemical methods to analyze extracellular electron transfer in E. coli, showing enhanced current production with vitamin K3 and partial direct electron transfer in biofilms.

The paper models the 2019-nCov epidemic in China, finding comparable transmissibility but lower fatality rates than SARS and MERS, and highlights the impact of early interventions.

The paper develops a brachial artery relaxation index (BARI) to predict abdominal aortic aneurysm (AAA) growth but finds no significant correlation between BARI and future AAA growth.