Z. Liu

This study investigates the distinct roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of factor V and factor VIII, revealing that MCFD2 binds cargo and LMAN1 acts as a shuttling carrier.

This study investigates the interactions between cisplatin and E-cadherin using fluorescence spectroscopy and AFM, revealing strong binding and structural changes.

This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.

The paper quantifies recombination rates and patterns in the human gut microbiome using sequenced fecal samples, revealing heterogeneities and the role of natural selection in variant spread.

This study shows that KSR1 is essential for maintaining the transformed phenotype of BRAFV600E mutant melanoma cells by promoting cell survival and inhibiting senescence and apoptosis.

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

The paper shows that positive co-operativity between membrane phase separation and surface polymer reorganization drives sensitive and selective condensate formation.

The paper integrates single-nucleus and spatial transcriptomics to map transitional states in soybean nodule symbiosis, identifying functionally distinct cell subgroups and a transitional infected cell subtype.

The paper shows that the IFNA pathway promotes aggressive KRASG12D-mutant pancreatic ductal adenocarcinomas through IFNAR1/STAT3 activation and identifies IFNAR1 inhibition as a potential therapeutic strategy.

This study tests an NLRP3 agonist added to PD-1/VEGFR inhibitors in murine HCC models with liver damage, finding it feasible but ineffective in improving tumor outcomes.

This paper introduces CREST, a CRISPR-based platform that enables simultaneous RNA modulation functions, reducing off-target effects and expanding transcriptome engineering capabilities.

This study identifies HCP5 as a key antiapoptotic factor in ESCC by preventing UTP3 degradation and activating c-Myc to suppress apoptosis.

This study identifies CSF1R-dependent macrophages as critical for epithelial regeneration after radiation-induced salivary gland injury.

This study shows SARS-CoV-2 requires acidic pH for membrane fusion and genome release, even after proteolytic cleavage by furin or TMPRSS2.

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

This study shows ethylene improves root hypoxia tolerance by reducing reactive oxygen species and inducing growth cessation in Arabidopsis thaliana.

This study identifies spatially resolved metabolite differences between stable and unstable human atherosclerotic plaques using mass spectrometry imaging and RNA-seq integration.

The paper shows that antibodies targeting CspZ FH-binding sites effectively clear Lyme borreliae in vitro and in vivo, highlighting their importance for vaccine development.

This study identifies a cooperative interaction between HAND2 and MYCN in neuroblastoma that regulates enhancer binding and gene transcription, and shows that targeting these factors suppresses tumor growth.

This study shows intermittent fasting improves cognitive function in Alzheimer's mice by reducing Aβ and neuroinflammation, and through gut microbiota and metabolite changes.

This study shows Hsp27 binds phosphorylated Tau to prevent its aggregation and mitigate AD pathology.

This study shows that hybrid immunity and vaccine boosters provide potent neutralizing activity against Omicron BA.1 and BA.2, while breakthrough infections induce nasal mucosal neutralization and identify an ultrapotent pan-variant antibody.

The paper identifies allosteric hotspots in bacterial transcription factors using deep mutational scanning and machine learning, finding that structural and dynamic properties are key predictors.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

This study uses electron tomography to analyze the structural transformation of prolamellar bodies into grana thylakoids in Arabidopsis cotyledons and identifies the role of CURT1 proteins in this process.

This study develops an immunocytokine (LH01) combining anti-PD-L1 and IL-15 to enhance antitumor immunity and overcome resistance to PD-L1 blockade in mouse models.

This study investigates the role of GDF15 in APAP-induced liver injury in mice, finding no significant ameliorative effect from overexpression or supplementation of GDF15.