Z. Zhang

This study uses scRNA-seq to classify PCCs into metabolism-type and kinase-type based on molecular features and microenvironment characteristics, suggesting potential therapeutic strategies.

This paper introduces a label-free technique to detect individual solution-phase molecules using microcavities, achieving high signal-to-noise ratios and resolving molecular radius and isomer mixtures.

This paper uses machine learning to identify latent transcriptional programs in squamous cell carcinomas from histology images, linking them to clinically relevant biological processes.

This paper introduces an epigenetic clock based on stochastic DNA methylation changes in plants, enabling high-resolution temporal analysis of phylogenetic relationships.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

This paper introduces an acoustically driven helical microrobot that mimics spirochete motion and demonstrates switchable directionality using a double-helix structure.

The paper identifies KCNN4 as a mediator linking PIEZO mechanotransduction to NLRP3 inflammasome activation, showing its role in CAPS-related auto-inflammation.

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

The paper characterizes the Kiwa defence system as a bacterial membrane supercomplex that detects phage-induced membrane changes and inhibits phage replication.

This study determines the structure of CTP/dCTP synthase bound to deoxynucleotides, revealing its bifunctional mechanism and cellular compartmentation potential.

This paper develops a deep learning method to assess chondrocyte viability using label-free two-photon microscopy images from rat and porcine cartilage, achieving 95% accuracy.

This study shows that GDF15 promotes osteoclast fusion and angiogenesis in endplate instability, and inhibiting GDF15 alleviates low back pain.

This study identifies Nr5a2 as a key driver of olanzapine-induced hyperphagia and weight gain by directly regulating Agrp expression in the hypothalamus.

This paper co-designs a low-complexity spike detection algorithm with a neural decoder to improve decoding performance and long-term stability while reducing bandwidth.

This paper investigates the cellular uptake, trafficking, and antisense gene regulation mechanisms of bottlebrush polymer-conjugated oligonucleotides in cancer cells.

The paper shows that air-liquid interface culture increases DRA expression and activity in Caco-2/BBe cells and colonoids by enhancing ceramide-rich platform formation and differentiation.

This paper develops cholesterol-deficient T cell membrane-coated nanoparticles to deliver STING agonists for tumor immunotherapy, showing improved blood clearance evasion and enhanced antitumor effects.

This study identifies O-GlcNAc glycosylation as a regulator of bone marrow stromal progenitor fate and niche function, influencing osteogenic/adipogenic differentiation and hematopoiesis.

The paper identifies chloride as an allosteric activator and inhibitor of Class-D beta-lactamases, revealing its dual role in enzyme kinetics and suggesting new antibiotic strategies.

The paper introduces ILEE, an unguided algorithm for accurate and automated quantitative analysis of cytoskeletal images, resolving limitations of existing methods and enabling novel feature measurements.

This paper introduces an inhomogeneous mathematical model based on the generalized logistic equation to describe tumor growth and treatment, validated against clinical observations and theories of tumor heterogeneity.

This study isolates urease-producing bacteria from the cultivation environment of Gracilariopsis lemaneiformis and shows they enhance urea uptake and nitrogen assimilation by the macroalgae.

This paper discovers Vibrio natriegens as a microbial platform for efficient formic acid utilization and remodeled it to enhance formate consumption and indigoidine production.

The paper determines the cryo-EM structure of the complete inner kinetochore of budding yeast, revealing its architecture and DNA interactions.

The paper reveals that Deltaproteobacteria, specifically Anaeromyxobacteraceae and Geobacteraceae, are widespread and dominant in soil nitrogen-fixing microbiomes, challenging previous assumptions about major nitrogen-fixing groups.

This study develops DNA vaccines encoding chimeric RBDs of SARS-CoV and SARS-CoV-2 variants, showing potent immunogenicity and broad neutralization against multiple variants.

This paper develops and evaluates ultra-low power MUA compression schemes for wireless iBMIs, finding that delta-asynchronous methods are optimal for short binning periods while synchronous methods are better for longer periods.

This study develops two quadrivalent mRNA vaccines against monkeypox virus and shows they induce antibodies, cellular immunity, and protection against Vaccinia virus in mice.

The paper identifies two Keap1 isoforms that interact with Smad2/3, enhancing their stability and transcriptional activity, and reveals a novel crosstalk between the Keap1-Nrf2 and TGF-β1-Smad2/3 pathways.