Z. Zhang

This study investigates the role of GDF15 in APAP-induced liver injury in mice, finding no significant ameliorative effect from overexpression or supplementation of GDF15.

The paper proposes a dynamic kissing model for enhancer-promoter communication within transcriptional condensates, supported by experimental data showing preference for spherical surface confinement.

The paper develops a method to rapidly quantify PHA in living cells using GFP-labeled phasins, achieving high accuracy with R-squares over 0.9.

This paper reports chromosome-level genome assemblies of five Sitopsis species and identifies the B-subgenome donor of bread wheat as an extinct species closely related to Ae. speltoides.

This study identifies acetylation as a regulatory mechanism in antibiotic resistance in E. coli, showing it negatively affects metabolism but positively influences motility, with PykF acetylation playing a key role.

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This study shows that primary human macrophages do not support SARS-CoV-2 replication and exhibit a limited cytokine response, unlike influenza viruses which induce strong IFN-β and proinflammatory cytokines.

This study evaluates PRKACA as a therapeutic target for fibrolamellar carcinoma using PDX models and shows that its knockdown or inhibition reduces tumor growth.

This paper develops a low-cost EEG-based BCI device using SSVEP decoding with CCA variants, achieving 95.56% accuracy and 102 bits/min ITR on an ESP32 microcontroller.

This paper evaluates amplitude threshold methods for spike detection, finding that noise-statistics-driven thresholds are less robust to parameter deviations than spike-noise-driven thresholds.

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

The paper finds that obesity is associated with reduced immune and inflammatory responses in COVID-19 patients, including lower expression of IFN and IFNγ response genes in lung and blood cells.

This study uses single-molecule techniques to analyze how phosphorylation and binding alter the conformational dynamics of the intrinsically disordered 4E-BP2 protein.

The paper describes the cryo-EM structure of the human inner kinetochore CCAN complex bound to a CENP-A nucleosome, revealing how it grips linker DNA for chromosome segregation.

This study investigates how homoeologous exchange affects gene expression and alternative splicing in synthetic allotetraploid wheat, finding cis- and trans-regulatory impacts on gene expression and AS events.

This study shows that SARS-CoV-2 vaccines induce T cell responses that cross-recognize variants from Alpha to Omicron, with high preservation of CD4+ and CD8+ T cell epitopes.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

The paper reports a cryo-EM structure of the SARS-CoV-2 Omicron spike protein, revealing how mutations alter its conformation and enable antibody resistance.

This study shows that UTX promotes glioblastoma progression by upregulating periostin expression, and its knockdown inhibits tumor growth and promotes apoptosis.

This paper identifies CaMK1D as a key mediator of ghrelin-induced food intake in AgRP neurons, showing its role in promoting orexigenic neuropeptide expression and obesity resistance.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

This study shows dihydroartemisinin (DHA) enhances anti-PD-1 therapy in hepatocellular carcinoma by inhibiting YAP1 and disrupting immune evasion through PD-L1, JAK1/STAT1, and JAK3 pathways.

The paper improves the reference genome annotation of Brassica rapa using PacBio RNA sequencing, identifying novel genes, correcting splicing errors, and characterizing alternative splicing and lncRNAs.