C. Li

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

The paper investigates how HetR controls gene expression from DIF1 motif promoters during heterocyst differentiation, showing dependence on HetZ and modulation by PatU3.

This study shows that Scutellaria baicalensis extract and its compound baicalein inhibit SARS-CoV-2 replication and 3CLpro activity in vitro.

The paper analyzes SARS-CoV-2 mutation dynamics, showing lower mutation rates than SARS and identifying an ACE2-binding affinity-reducing RBD mutation from an Indian sample collected in January 2020.

The study shows that organic manure and rice straw residue increase soil microbial diversity and abundance in double-cropping paddy fields compared to chemical fertilizer alone or no fertilizer.

This study identifies a regulatory mechanism where coupled Ca2+-regulatory mechanisms on both sides of the mitochondrial inner membrane control MCU-mediated Ca2+ uptake.

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

This paper introduces an ultrasensitive fluorogenic probe for detecting human heparanase activity with a picomolar detection limit and demonstrates its use in high-throughput inhibitor screening.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

This study shows that FcRn, not FcγRs, is responsible for maternal-fetal transport of IgG antibodies, suggesting FcRn engineering could improve antibody transfer to the fetus.

OsFIT interacts with OsIRO2 to enhance its nuclear accumulation and activate Fe-uptake gene expression in rice.

This study investigates how white leaves in Actinidia kolomikta attract pollinators and maintain photosynthetic capacity, enhancing reproductive fitness through dual functions.

The paper uses a within-host viral dynamic model to estimate the basic reproductive numbers of SARS-CoV-2 and MERS-CoV using chest radiograph data.

The paper identifies a ciliary tip signaling compartment formed by intraflagellar transport and shows it is essential for salt detection in C. elegans.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

The paper presents seven new exon probe sets and a bioinformatics pipeline for fish phylogenomics, enabling accurate phylogenetic analysis by filtering paralogs and integrating old and new data.

This study shows that the SARS-CoV-specific antibody CR3022 binds strongly to 2019-nCoV RBD with a KD of 6.3 nM, while other antibodies targeting the ACE2 site fail to bind, highlighting the importance of RBD differences for cross-reactivity.

This study profiles microbial activities in deep sea cold seep sediments, revealing hydrocarbon oxidation pathways and their role in sustaining diverse microbial communities across redox gradients.

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

The paper uses a quantitative platform and statistical methods to map pharmacogenomic responses in lung cancer, revealing complex genotype-specific therapeutic interactions.

This study analyzes HTNV genetic diversity and evolution in China and neighboring regions, identifying phylogroups, recombination events, and geographic clustering patterns.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

This study examines how social support moderates the relationship between role conflicts and job satisfaction among nurses with multiple roles in China.

The paper identifies dozens of QTL for leaf angle across eight leaves in maize under three environments, revealing genetic architecture differences at various canopy levels.

This paper sequenced two millipede genomes, revealing unique genomic features, defense systems, and microRNA regulation mechanisms in myriapods.

The paper shows that varying transcription levels of the lncRNA IRT2 in yeast lead to opposing chromatin and transcription states, influencing gene expression and cell fate decisions during meiosis.

This study identifies Cqs2 as the critical determinant for orchestrating the unisexual cycle in Cryptococcus neoformans without requiring the sex-determination program.

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.

This study examines how CO2 responses of photosynthesis in Hippophae rhamnoides leaves vary under different soil moisture conditions using multiple models.

This study applies r- and K-selection to HeLa cells to show how life history strategies influence tumor functional diversity through gene expression and ecological competition.