G. Wang

The paper develops a discrete dynamic model for human epidemics and identifies key parameters influencing total cumulative cases through sensitivity analysis.

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

The paper shows that acetyl-CoA depletion disrupts nucleolar integrity, activates p53 via ribosomal proteins, and is mediated by class IIa HDACs regulating nucleolar phase state.

This study examines bacterial community diversity and structure across different rhizocompartments of desert leguminous plants, revealing significant niche-driven variability and core microbiomes.

This study identifies cinnamoyl-CoA reductases (CCR) as benzaldehyde synthases in cucumber, showing their specific expression and enzymatic activity in roots and flowers.

This study shows RTR-1, a compound from Rhodomyrtus tomentosa, inhibits gastric cancer cell proliferation by inducing ER stress and blocking the STAT3 pathway, while causing G2/M phase cell cycle arrest.

This study shows that PPAR-α activation increases herpesvirus replication, suppresses type I interferon, and inhibits STING signaling through ROS.

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

The paper uses MD simulations to study ligand transport by P-gp and shows lipids also play a role in this process.

The paper uses a biogeochemistry model to project changes in alpine grassland carbon dynamics under climate change and elevated CO2, finding a net carbon sink with decreasing sequestration capacity and precipitation's growing role.

The paper identifies a moth pheromone receptor not belonging to the known subfamily, suggesting two independent origins of type I pheromone tuning in Lepidoptera.

The paper identifies chromatin state transitions in rice shoots under phosphate starvation that correlate with differentially expressed genes involved in cell wall remodeling.

This study analyzes four genomic biomarkers in 1,000 Chinese cancer patients to assess their distribution and associations with cancer types and mutations.

This study identifies miR-466d-3p as a target of JEV NS3 that regulates IL-1β and viral replication through miRNA degradation.

This paper introduces a Tmem119-tdTomato reporter mouse model to specifically study microglia in the CNS, showing tdTomato+ cells are microglia-specific and detectable in health and disease.

The paper uses single-cell multi-omics to identify aberrant megakaryocyte pathways in myelofibrosis and discovers JAK2-mutant-specific targets for immunotherapy.

This study develops the first low nanomolar LRH-1 agonist using structure-guided design, showing increased potency and anti-inflammatory effects in an organoid model.

The paper compares transcriptome profiles of maize CSSLs I178 and X178 under accelerated ageing to identify genes and alternative splicing events associated with seed longevity.

The paper identifies differentially expressed proteins in tumor-associated vascular endothelial cells of colorectal cancer and links some to angiogenesis and metastasis.

This paper identifies ELF1 as a non-canonical regulator of antiviral ISG expression, showing it amplifies and prolongs the type I interferon response by inducing a distinct set of antiviral genes.

The paper examines how one-time nitrogen fertilization affects soil microbiomes in switchgrass fields, finding that spatial and temporal variation outweighs fertilization effects.

This paper evaluates the structural and practical identifiability of a dual-input kinetic model for FDG PET in liver inflammation using Monte Carlo simulations and patient data.

This paper validates a low-cost cryoablation system using carbon dioxide for tumor ablation in resource-constrained settings, showing effective necrosis in rat and porcine models.

This study investigates DNA unwinding by the hexameric helicase G40P using single-molecule fluorescence, revealing single base pair unwinding and coordinated ATP hydrolysis.

This study shows that DSBA protects bone marrow cells from radiation toxicity by activating Nrf2 and stress response genes in mice.

This study identifies a novel maize gene, glossy6, involved in epicuticular wax trafficking and drought tolerance by analyzing a mutant with reduced wax load and increased water loss.

This study investigates how peiminine induces apoptosis in HepG2 cells through both extrinsic and intrinsic pathways, showing dose- and time-dependent effects.

This study shows that gut segments, not diet, are the main factor shaping the intestinal microbiome in grass carp, with diet having a smaller impact in distal gut regions.

This study identifies lncRNAs associated with cancer prognosis by integrating RNA-seq and microarray data across 20 cancer types.

This paper introduces a spatiotemporal kernel method for dynamic PET reconstruction, achieving better noise reduction and performance compared to spatial kernel and conventional ML methods.