H. Chen

The paper designs novel protein sequences using a Graphormer-based model and validates them on CalB hydrolase, achieving 1.7x higher specific activity than the wild type.

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

This study identifies NS2's SUMO-interacting motif as critical for avian influenza virus adaptation to mammals by enhancing vRNP assembly and ANP32A/B interactions.

This paper describes a FACS method using quantum dots to isolate high-quality conformational antibodies against insoluble antigens like amyloid fibrils.

The paper measures the motion and transcriptional dynamics of DNA loci pairs in fly embryos, finding compact organization and fast dynamics that affect gene regulation.

This study shows that the stem-loop II motif in SARS-CoV-2 is not essential for viral growth in vitro or in vivo.

MAPS provides pathologist-level cell type annotation from spatial proteomics data using machine learning, outperforming existing methods in speed and accuracy.

KaScape quantitatively characterizes TF-DNA binding affinity across all possible sequences using next-generation sequencing and provides a tool to visualize the affinity landscape.

This study shows that a PTP1B/PTPN2 inhibitor enhances T cell anti-tumor immunity in mice, improves tumor response to PD1 therapy, and avoids immune-related toxicities.

This study identifies TARBP1 as a driver gene in hepatocellular carcinoma that promotes tumor progression by methylating tRNA and enhancing glutamine metabolism.

This study establishes mouse models of Cdk5-driven Medullary Thyroid Carcinoma (MTC) that recapitulate human tumor aggressiveness and identifies metabolic pathway perturbations as critical for aggressive growth.

This study uses single-nucleus RNA sequencing to create a cell atlas of deep-sea mussel gills, revealing cell types and their roles in supporting chemosynthetic symbiosis and environmental adaptation.

This study identifies FOXK2 amplification and overexpression in breast cancer, showing its role in promoting tumor growth, chemoresistance, and synergistic therapeutic responses when targeted with PI3KCA inhibitors.

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

This study identifies genetic markers and candidate genes associated with day-neutral flowering in Cannabis sativa using a segregating F2 population and genome-wide association analysis.

The paper introduces a self-supervised denoising method for structured illumination microscopy that enables high-quality super-resolution imaging with reduced fluorescence.

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

The paper identifies RipBH, a virulent type III effector from Ralstonia solanacearum, which induces autophagy-associated cell death and is essential for potato brown rot pathogenesis.

This study presents chromosome-level genome assemblies of seagrass species and identifies ancient and recent genome duplication events linked to adaptation to marine environments.

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

This study uses proximity biotinylation to identify RAB18 interactors, revealing its role in sterol mobilization and biosynthesis, with implications for Warburg Micro syndrome.

The paper reports structures of Las1-Grc3 complexes and identifies their role in pre-rRNA cleavage during ribosome biosynthesis.

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

This study identifies CRB3's role in navigating Rab11 vesicles to promote γTuRC assembly during ciliogenesis and its regulation of Hh and Wnt signaling in tumorigenesis.

This study reveals that CD69 acts as a transmembrane protein agonist of S1PR1, promoting Gi-dependent internalization and inhibiting lymphocyte egress.

This study examines the role of perineuronal nets in the insula of male and female mice in aversion-resistant ethanol consumption, finding sex-specific differences in PNN structure and behavior.

This study shows that cannabidiol (CBD) significantly enhances TRPV2 channel activation by 2-APB but not by heat, revealing multiple CBD binding sites and mechanisms.

This study identifies HEV-ORF3 as a prion-like protein that facilitates virion release and pathogenesis by forming filamentous structures, highlighting its role in viral assembly.

The paper compares the roles of TIR1 and AFB1 in transcriptional and rapid auxin responses, showing their distinct functions are due to specific protein properties, not subcellular localization.