H. Liu

The paper presents cryo-EM structures of bombesin receptors bound to their neuropeptide ligands, revealing the mechanism of ligand selectivity and receptor activation for itch treatment.

The paper traces the evolutionary origin of brackish archaea, showing gene rearrangements enabled their adaptation to coastal environments after the Cryogenian Snowball Earth.

The paper uses single-cell RNA-seq to analyze factors influencing CD4 T cell activation and identifies distinct functional states and differentiation patterns.

This study shows that pre-activating γδT cells with IL-12/18/21 enhances their anti-tumor activity and overcomes resistance to anti-PD-L1 therapy in mouse models.

The paper analyzes marmoset monkey vocalizations to show that call patterns encode emotional states and transmit emotion between individuals.

This paper reports a high-affinity antibody that binds to a glycopeptide with consecutive glycosylation sites, showing that glycan modification near the epitope significantly increases antigenicity.

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.

This study shows that increased hepatic Activin A expression reduces atherosclerosis by lowering cholesterol, inflammation, and fat accumulation in LDLR-/- mice on a Western diet.

The paper investigates how phase separation of N-myc affects gene transcription and finds that only a small fraction of N-myc-regulated genes are influenced by this process.

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

This study shows that exosomes from splenic ischemic preconditioning reduce renal ischemia-reperfusion injury by decreasing inflammation and apoptosis.

This study shows that rotating tomato with eggplant or arrowhead improves rhizosphere bacterial diversity, enzyme activity, and tomato yield and quality while reducing nitrate content.

This study investigates how Mikania micrantha responds to Puccinia spegazzinii infection using metabolomics and transcriptomics, identifying changes in metabolites and gene expression.

This paper develops a modular chemoenzymatic method to synthesize diverse C14-functionalized steroids using a novel CYP14A enzyme and its variants.

This study shows that female mice have stronger and more diverse antibody responses to influenza vaccination, leading to better protection against mutant viruses due to increased germinal center B cell activity.

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

The paper evaluates the potency of mAb J08 against SARS-CoV-2 variants using cell-based assays and cryo-EM, showing its resistance to escape mutations and broad binding capability.

This study evaluates the short-term and long-term effects of four antibiotics on the murine intestinal microbiota, finding long-term negative impacts and increased risk of disease.

This paper introduces Wolffia australiana as a model system for studying plant morphogenesis using a Plant-on-Chip culture system and advanced technologies like snRNA-seq.

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

This study investigates the structural and biochemical features of Omicron BA.1 and BA.2 variants, showing increased infectivity and mouse ACE2 binding compared to wildtype, suggesting a potential human-cat-mouse-human transmission cycle.

This study examines seasonal changes in litter and soil carbon dynamics in mixed coniferous forests through freeze-thaw experiments, revealing how temperature fluctuations affect carbon release and mass loss.

This paper develops aminoadamantane nitrate compounds that inhibit SARS-CoV-2 infection by S-nitrosylating ACE2 and blocking viral entry, showing efficacy in vitro and in a Syrian hamster model.

This study identifies climate-associated genetic variants in Populus koreana and predicts its future climate change vulnerability using genomic and environmental data.

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

This study shows that a UB-612 booster vaccine significantly increases neutralizing antibodies against SARS-CoV-2 variants, including Omicron, with estimated 95% efficacy against the ancestral strain.

The paper identifies a broadly neutralizing epitope in SARS-related coronaviruses that is effective against variants, including Omicron, and suggests its use for universal vaccine design.

The paper compares thermophysiological traits of three CRD1 Synechococcus strains from different thermal niches, showing distinct thermotypes despite lacking typical cold thermotype features.