J. Zhang

The paper reports cryo-EM structures of the SARS-CoV-2 spike protein with the D614G substitution, showing how the mutation affects trimer stability and infectivity.

The paper investigates the ftin gene's role in wheat under cold stress, finding it inhibits spike development through multiple pathways and phenotypic changes.

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

This study investigates how MFG-E8 signaling contributes to age-related arterial damage, showing that its deficiency reduces elastolysis, fibrosis, and calcification in mice.

Introgression of the 1Ay21* HMW-GS increases wheat grain protein content and improves bread-making quality by reshaping the grain proteome network.

This study compares the temporal transcriptomes of two Verticillium dahliae strains to identify pectin degradation genes linked to pathogenicity in Upland cotton.

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

This study identifies 129 loci associated with 27 yield-related traits in tomato, explaining 8.8% of phenotypic variance, and highlights a candidate gene involved in leaf stomata formation and drought resistance.

This study identifies CDF-1 and SUR-7 as regulators of lipid metabolism in C. elegans, linking zinc homeostasis to lipid accumulation via the SREBP-SCD pathway.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

This study shows that reduced IF1 in obesity leads to mitochondrial reprogramming through ANT2 downregulation, improving insulin sensitivity despite increased body weight on a high-fat diet.

This study shows that inactivating ATPIF1 enhances CD8+ T cell antitumor activity by reprogramming their metabolism, leading to better tumor suppression in mouse models.

SingleChannelNet is a deep learning model that automatically classifies sleep stages from raw single-channel EEG data, achieving high accuracy without hand-crafted features or multi-modality data.

This study identifies CVB3 VP1 as an inhibitor of cell proliferation by disrupting MAT1 interaction with the CAK complex, thereby blocking CAK-CDK4/6-Rb signaling in pancreatic cells.

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

This study shows that lymph flow directs neutrophil migration in lymph nodes during infection by transporting chemokines, and impaired flow leads to persistent infection.

This study examines how ethanol intoxication affects blood-based biomarkers of cerebral injury in mice after traumatic brain injury, finding differential impacts on NSE and NFL levels.

The paper assesses the impact of different land-use scenarios on ecosystem services in Nanjing from 2000 to 2015, showing varying effects on carbon storage, habitat quality, and water yield.

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

The paper identifies novel alternative splicing events in early-onset gastric cancer and links them to protein modification and immune microenvironment changes.

The paper analyzes SARS-CoV-2 quasispecies structure using SMRT sequencing, revealing a One-King model with dominant and minor haplotypes and their evolutionary dynamics.

The paper investigates the role of hydrophobin-enriched vesicles in mold sporulation, showing their intracellular accumulation and secretion contribute to spore hydrophobicity and rapid sporulation.

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

This study identifies SARS-CoV-2 ORF9b as a viral protein that inhibits type I and III interferon responses by disrupting multiple innate antiviral signaling pathways.

This study develops a graphene oxide-alginate-gelatin bioink for 3D bioprinting of bone-mimicking scaffolds that enhance scaffold fidelity, osteogenic differentiation, and mineralization.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This paper introduces a technique combining label-free histology with spatially resolved multi-omics to map gene expression and copy number alterations in human oral squamous cell carcinoma.

The paper examines gut microbial communities in phenotypically divergent populations of Chilo suppressalis, finding variations linked to diet and gut compartments.