J. Zhao

This study shows FAM76B inhibits NF-κB-mediated inflammation by affecting hnRNPA2B1 translocation in vitro and in a TBI mouse model, and identifies its interaction with hnRNPA2B1 in human TBI and neurodegenerative disease tissues.

The paper identifies the abfA cluster as a key genetic factor for arabinan utilization in gut microbiota, showing its therapeutic potential for constipation through improved gut motility and metabolite production.

This study reveals the structural basis of BIRC6's role in balancing apoptosis and autophagy by showing its dimeric structure and interactions with Smac/DIABLO, caspase 3, HtrA2, and LC3.

The paper shows cpSRP54 and FtsH work together in thylakoid membrane protein quality control during de-etiolation in Arabidopsis, and provides a trackable marker for monitoring their activities.

The paper investigates phage resistance mechanisms in Klebsiella pneumoniae and shows how these can both increase and decrease antibiotic susceptibility.

This study shows GLUT3 is essential for M2 macrophage polarization and function by regulating endosomal IL-4/STAT6 signaling.

The paper presents the crystal structure of the Bre1 RBD-Rad6 complex and shows how their interaction activates Rad6 for H2Bub1 catalysis.

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

The paper identifies telocytes as regulators of macrophage activity in periodontitis through HGF/c-Met signaling, showing they shift macrophages to an M1/M2 hybrid state.

This study develops an autologous humanized PDX model to study tumor-immune interactions and demonstrates its utility in preclinical testing by showing VEGF-A inhibition reduces tumor growth.

This paper identifies a 4-bp deletion in the maize ZmSOS1 gene that causes salt sensitivity and develops a molecular marker to improve salt tolerance in breeding programs.

The paper reports the cryo-EM structures of the BfpD ATPase from EPEC in different nucleotide states, revealing divergent quaternary configurations and suggesting a new mechanism for T4P extension.

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

This study shows that APOE deficiency in human iPSC-derived cerebral organoids disrupts lipid homeostasis and affects cholesterol biosynthesis and neurogenesis.

This study identifies Carmn, a SMC-specific lncRNA, as critical for maintaining GI smooth muscle contractile function and motility, with loss of function leading to impaired contractility and pseudo-obstruction.

This paper introduces a computational method to identify atrial regions susceptible to micro-reentry by modeling percolation-like phenomena on spatial networks of atrial fibre maps.

This study defines the ligand-dependent interactome of the Sigma 1 Receptor using biotinylation and mass spectrometry, revealing novel interactions and functional roles in cholesterol metabolism.

This study links gut microbial depletion of Lachnospiraceae genera to lower HDL-C and hypertension in a high-calorie diet population, suggesting HDL-C as a mediator.

This study identifies USP11 as a deubiquitinase that stabilizes HINT3, promoting endothelial apoptosis-resistance in pulmonary hypertension.

This study identifies genomic adaptations in Leuciscus waleckii to extreme alkaline environments through genome assembly and population analysis.

This study shows that inhibiting ABL1 kinase reduces genomic instability and enhances the efficacy of chemotherapy in multiple myeloma.

This study shows intermittent fasting improves cognitive function in Alzheimer's mice by reducing Aβ and neuroinflammation, and through gut microbiota and metabolite changes.

This study identifies the N-terminal domain (NTD) of p53 as the major binding site for Cyclophilin D, revealing dynamic electrostatic interactions and a minimal binding region for mPTP regulation.

This study identifies APE1 as a driver of genomic instability in solid tumors, showing its role in chemoresistance and tumorigenesis through effects on DNA repair and genome stability.

This study shows that PKD promotes prostate cancer bone metastasis by regulating Runx2 via MEK/ERK1/2 signaling, and inhibiting PKD reduces metastasis in mice.

The paper shows that phase-separated TRB proteins aggregate with PRC2 to enhance Polycomb silencing in plants.

This study maps single-cell transcriptomes and T cell repertoires in Behcet's disease to identify immune mechanisms and T cell trajectories in vascular and dermal manifestations.

This paper reports chromosome-level genome assemblies of five Sitopsis species and identifies the B-subgenome donor of bread wheat as an extinct species closely related to Ae. speltoides.

The paper identifies CFS1 as an autophagy adaptor that connects autophagosomes with the ESCRT-I component VPS23 to form amphisomes, facilitating vacuolar delivery in plants.