M. Li

This study shows that natural selection on both amino acid sequences and expression levels determines ohnolog retention, providing a unified framework for understanding this evolutionary phenomenon.

This study investigates how cardiolipin and phosphatidylglycerol lipids induce structural and dynamic changes in cytochrome c, affecting its peroxidase activity during mitochondrial apoptosis.

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

This paper re-examines fidelity-speed and fidelity-proofreading cost trade-offs in DNA replication under the exonuclease-proofreading mechanism using a first-passage method.

This study shows that Arabidopsis CIL and CIA2, paralogous genes involved in chloroplast development, have partially overlapping functions, with CIL localized to the nucleus and CIA2 possibly localized to chloroplasts.

This study shows that glycolysis fuels PI3K signaling in CD8+ T cells, linking metabolic reprogramming to T cell immunity and suggesting therapeutic targets for infectious diseases and cancer.

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

This study uses a new phenotyping approach to analyze color patterns in coleus plants and identifies features driving breeder and consumer preferences.

The paper describes a novel Thermoleptolyngbya strain, identifies it as a new species using phylogenetic and genomic analyses, and explores its genomic features and adaptive capabilities.

This study identifies Subgroup 2 R2R3-MYBs as key regulators of the stilbenoid pathway in grapevine by integrating DAP-Seq and co-expression networks.

This study compares 15 fish species to identify genomic signatures of alkaline adaptation in both highland and lowland fish, finding consistent patterns of accelerated evolution and positive selection in shared genes.

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

This study designs a de novo regulation system using TFs and CREs to alter plant secondary metabolism, showing reduced tobacco alkaloids and nitrosamines in engineered plants.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

This study shows the D614G mutation in SARS-CoV-2 spike enhances lysosomal trafficking and accumulation, contributing to increased infectivity and transmission.

The paper develops a method to measure subnanometer position changes of biomolecules in live cell plasma membranes using extracellular quenchers and validates it by studying peptide-induced membrane perforation.

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

This study shows SIB1 and LSD1 antagonistically regulate GLK1/2 to control PhANGs expression, affecting chloroplast biogenesis and 1O2 homeostasis in Arabidopsis.

This study identifies a conserved ubiquitin- and ESCRT-dependent pathway for degrading lysosomal membrane proteins in human and yeast cells.

This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.

The paper profiles human fetal liver hematopoietic stem cells using multi-modal data to identify a molecular signature associated with engraftment potential.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

This paper characterizes bacteriophage JD419, which has a broad host range and retains lytic activity under various conditions, and reports its genome lacking virulence or antibiotic resistance genes.

Two diketopiperazines (DKPs) produced by sporulating Bacillus thuringiensis stimulate diatom P. tricornutum growth and increase lipid content.

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

This study develops a model to characterize cell membrane mechanics using relaxation curves from optical tweezers, revealing insights into cell skeleton changes and protein diffusion.

This paper examines how structural geometry, assembly energetics, and cargo release kinetics interact in sub-20 nm nanocarriers, showing that small molecule compatibility and release behavior are influenced by these factors.

The paper investigates how Rad6/Rad18 complexes move along RPA filaments to regulate PCNA monoubiquitination during translesion DNA synthesis.

This study investigates the pharmacokinetics and pharmacodynamics of inhaled phage PEV31 in mice, showing reduced MDR Pseudomonas aeruginosa burden.

This paper examines the theoretical basis of two DNA polymerase fidelity assays and shows they only accurately quantify proofreading efficiency under specific kinetic parameter constraints.