W. Zhao

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study shows that the intrinsically disordered region of FBP17, not its F-BAR domain, is responsible for curvature sensing in membrane dynamics.

This study identifies site-specific O-glycosylation patterns in SARS-CoV-2 spike proteins, revealing host-dependent variations and their potential implications for viral function and therapeutic development.

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

This study identifies the PacC-dependent pH signaling pathway in the rice blast fungus Magnaporthe oryzae, showing it regulates host pH changes and the switch between biotrophic and necrotrophic growth, essential for disease development.

The paper identifies compounds that inhibit SARS-CoV-2 3CLpro enzyme activity, with auranofin showing strong inhibition and potential for COVID-19 treatment.

The paper shows that viral DNA packaging motors switch between helical and planar symmetry to translocate double-stranded DNA.

The paper introduces a low-cost, portable imaging system for specific COVID-19 antibody testing using microarrays, achieving performance comparable to expensive commercial readers.

This study shows that dynamic mechanical cues in crowded cell populations enhance collective responses in NF-κB signaling and nuclear shape fluctuations through mechano-signaling feedback loops.

A 573 bp insertion in the YFT1 gene's 5' UTR disrupts ethylene signaling and carotenoid synthesis, causing yellow fruit in tomato mutants.

This study uses single-cell RNA-seq to analyze cell type-specific drug responses in human tumor tissues, revealing personalized therapeutic strategies for solid tumors.

This study shows pen-strep increases macrophage stiffness and promotes cell spreading on various ECM substrates through YAP-1/TAZ upregulation and β1 integrin downregulation.

This study identifies an optimized mRNA UTR combination (NASAR) that significantly enhances SARS-CoV-2 antigen expression in vitro and in vivo.

The paper develops CAR-expressing iPSC-derived macrophage cells with antigen-dependent anti-cancer functions effective against both liquid and solid tumors.

The paper characterizes site-specific N-glycosylation of SARS-CoV-2 spike proteins expressed in human and insect cells, revealing differences in glycan types and their implications for infection and vaccine development.

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

This study develops a serum-free method to generate human mesenchymal stem cell spheroids using knockout serum replacement, showing similar transcriptomes to FBS-based spheroids and retained MSC markers.

This study compares serial X-ray crystallography and MicroED for determining structures from small macromolecular crystals, highlighting their strengths and challenges.

This paper introduces CellGPS, a method to track single cells in vivo using PET and MSN, demonstrating real-time tracking of a breast cancer cell in a mouse model.

This study shows N-acetyl cysteine (NAC) alleviates Coxsackievirus B-induced myocarditis by inhibiting caspase-1 and viral proteases, offering a potential therapeutic option.

The paper shows that 3D matrix stiffness and dimensionality influence the expansion of hematopoietic stem and progenitor cells in vitro, affecting lineage fractions and gene expression.

This paper identifies the role of TYLCV V2 protein in facilitating the nuclear export of V1 protein and viral systemic infection through host exportin and V1-V2 interaction.

This study evaluates polishing and pre-coating techniques for FIB-milled crystals in MicroED, finding that platinum pre-coating and polishing improve signal-to-noise ratio, resolution, and refinement statistics.

This paper introduces a method to prepare protein crystals for continuous rotation MicroED using ion beam milling, eliminating the need for blotting optimization.

This study shows PARP inhibitors trigger an immune response via the STING pathway, enhancing immune checkpoint blockade efficacy regardless of BRCA mutations.

This study isolates and characterizes a wheat-specific phosphate-solubilizing Pseudomonas strain, showing its ability to colonize the wheat rhizosphere, enhance growth, and downregulate the phosphate transporter gene TaPT4.

This study shows metformin improves uterine progesterone signaling in PCOS-like rats by reducing PGR and ER expression and correcting gene expression abnormalities.