X. Liu

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

This study samples ileocecal microbiome in situ using transendoscopic tubing and finds distinct metatranscriptomes compared to fecal samples, diurnal rhythms in bacterial activity, and metabolomic parallels to gut microbiome changes.

This study identifies how type I interferon remodels lysosomes to enhance Salmonella virulence and pathogenesis in intestinal epithelial cells.

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This study identifies a novel RecJ from Bacillus alcalophilus with endonuclease activity, distinct from previously known exonucleases, and highlights its potential as a gene editing tool.

This paper reports the cryo-EM structure of human RFC bound to PCNA, revealing an autoinhibited conformation and a novel regulatory mechanism for AAA+ ATPases.

The study identifies AD1, a 3-KETOACYL-CoA SYNTHASE gene regulated by FUSED LEAVES1, as essential for cuticle formation and organ separation in maize.

This study reveals that the Ocr protein from bacteriophage T7 inhibits host transcription by binding to RNA polymerase and competing with sigma factors, providing a structural basis for its dual role in evading host defenses.

This paper introduces a novel tissue biopsy culture method that improves fungal detection compared to traditional methods.

The paper develops a computational model of cambium activity to simulate radial plant growth by integrating regulatory factors and physical constraints.

This study shows that a diversified learning environment improves active avoidance learning and mitigates stress-induced learning impairments in animals.

This study introduces DeRetro, a deep learning framework for retrosynthesis that improves performance and explainability by decomposing the task into reactive center prediction and molecule generation.

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.

This study compares the roles of fibroblasts and pericytes in supporting endothelial cell self-assembly into perfusable microvascular networks in vitro.

The paper identifies endoimmune cells, a novel subpopulation of endothelial cells in zebrafish, using single-cell RNA sequencing and shows their involvement in immune responses.

This study shows that positional isomers of a synthetic non-nucleoside triphosphate can differentially control myosin function by altering force and motion generation without changing myosin structure.

The paper identifies P5CS as a CTPS-interacting protein in Drosophila and shows they form cytoophidia, linking two enzymes in pyrimidine and proline biosynthesis.

This study examines testosterone level changes in female giant pandas during estrus and finds that testosterone peaks 4 days after estradiol peaks and is only correlated with estradiol after the estradiol peak.

A vaccine targeting viral protease cleavage sites provides >80% protection against vaginal SIVmac251 infection in macaques by inducing T cell responses and a protective immune environment.

This study develops an anti-somatostatin receptor 2 antibody-drug conjugate (ADC) that effectively targets and kills neuroendocrine tumors with minimal toxicity.

This study shows that senescence of alveolar type 2 stem cells drives pulmonary fibrosis and that targeting p53 or Tgfβ can block fibrogenesis.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This study identifies an insulin-stimulated proteolytic mechanism linking energy expenditure with glucose uptake through TUG cleavage and its nuclear effects.

This study shows that AHLs affect spore germination in the moss Physcomitrella patens and that sporophytes are associated with AHL-producing bacteria.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

The paper analyzes non-additive effects in mixed-species litter decomposition, finding synergistic and antagonistic effects under different conditions.

This study shows that transient Dux overexpression improves SCNT and chemical reprogramming efficiency, while Dppa2/4 do not, and Dux treatment makes SCNT embryos resemble fertilized embryos.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.