X. Wu

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

This study shows FTO stabilizes LINK-A, promoting ESCC progression through MCM3-mediated cell cycle progression and HIF-1α activation.

This paper introduces multifunctional ferromagnetic fiber robots capable of navigation, sensing, and treatment in minimally invasive surgery, demonstrating their use in electrophysiology sensing and localized treatment.

HYENA identifies oncogenes, including non-coding genes, activated by enhancer hijacking in cancer using whole-genome and transcriptome sequencing data.

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

The paper introduces a metadata catalog to enhance findability of sickle cell disease studies using FAIR principles through curated metadata and search tools.

The paper identifies eEF2 as a prognostic biomarker for dense connective tissue repair outcomes and shows it regulates cellular processes to improve healing.

This study isolates a CPR bacterium using epicPCR and reveals its type IV pili-dependent epibiotic lifestyle and twitching motility.

This study shows adenoviral infection causes arrhythmogenic changes in the heart before significant immune response, through gap junction and ion channel dysfunction.

This paper identifies CX3CR1+ CD8+ T cells with low mitochondrial membrane potential as functionally resilient, showing high cytotoxicity and reduced ROS through ME1 upregulation, which enhances their anti-tumor activity.

This study shows that combining mesenchymal stromal cells and alpha-1 antitrypsin significantly improves inflammation modulation and resolution in vitro and in a mouse model.

This study shows that fibronectin improves calcium signaling and myofilament activation in diabetic cardiomyocytes by enhancing integrin-ECM interactions and mechanical properties.

The paper identifies beta-oscillations in cortico-striatal regions as markers of learned reward value across multiple behavioral tasks in rats.

The paper reports cryo-EM structures of cyanobacterial transcription initiation complexes and identifies an SI3-{sigma} arch that stabilizes the RNAP-promoter DNA open complex, essential for transcription initiation.

The paper identifies PELO as a catalyzer required for the ATPase activation and sequential assembly of NLR family proteins into functional complexes.

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

This study compares water use strategies in soybean and cowpea under drought using phenomic and transcriptomic analyses, identifying gene networks and regulatory mechanisms underlying their contrasting responses.

The paper develops a single-well droplet digital PCR method to simultaneously detect pathogen and host allele types, showing DRB3*009:02 alleles suppress BLV proviral load.

This paper develops a visual perception system using pose estimation to analyze fish swimming and provides code and dataset for the method.

This study analyzes codon usage changes in SARS-CoV-2 over time, finds that deoptimization may reduce protein expression, and designs codon-optimized mRNA vaccine candidates for Omicron variants.

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

This study identifies HCP5 as a key antiapoptotic factor in ESCC by preventing UTP3 degradation and activating c-Myc to suppress apoptosis.

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

This paper identifies a new class of TEAD-YAP inhibitors with a novel binding mode that suppresses transcriptional activity and shows anti-proliferative effects in cancer cells.

This paper develops an imaging flow cytometry method to quantify temperature-induced platelet shape change, showing a consistent transition from fusiform to circular shapes in mouse and human platelets.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.