Y. Li

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

The paper quantifies intraROS and apoROS accumulation in wheat infected by Bgt, showing that intraROS contributes to localized cell death in NLR R gene lines, while unconventional R genes show reduced intraROS responses.

This study uses optical metabolic imaging to show diet and sex influence lipid metabolism in aging Drosophila brains, revealing IIS pathway involvement.

The paper investigates L1 retrotransposition in HGSC, finding that despite high L1 mRNA expression, only a third of tumors show somatic insertions, with variability in retrotransposition frequency and patterns.

This study investigates how metabolic acids like citrate and lactate influence the 3D architecture of bone mineral through synthetic apatite formation.

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.

This study identifies a novel immune system, Juk, in Pseudomonas aeruginosa that targets jumbo phages by inhibiting early phage transcription, DNA replication, and nucleus assembly.

This study shows that p53 deficiency in tumors enhances immunogenicity by increasing IL-33, which improves response to PD-1 ICB therapy in a mouse model.

This study shows microglia support cryptococcal brain infections by hosting fungal growth and facilitating copper acquisition, and demonstrates that IFNγ can block this process.

The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.

The paper compares anti-viral immune responses between individuals of Indian and European origin, finding differences in chromatin accessibility and transcriptional responses to viral stimulation, which may explain variations in COVID-19 susceptibility.

This study identifies three evolutionary states of ovarian high-grade serous carcinoma using whole-genome sequencing and links them to distinct therapeutic targets.

This study investigates the evolutionary conservation of m6A-related genes in insects and identifies METTL3's role in silkworm embryonic development through functional analysis.

The paper identifies 'active bulging' as a process that promotes biofilm formation in bacterial swarms through liquid bulge formation and cell density manipulation.

This study identifies ATF3 as a key regulator that preserves skeletal muscle stem cell quiescence by preventing premature activation and maintaining genome stability.

This study identifies how Plasmodium falciparum proteins hijack human IgM to evade immune responses and cause severe malaria.

This study identifies GATA2/3 and MSX2 as key regulators of ERV-derived enhancers in human trophoblast stem cells, revealing their role in placental gene regulation.

This study compares Babesia and Plasmodium genomes and gene expression to explain why Babesia is not killed by artemisinin, finding differences in haem synthesis, iron utilization, and gene expression.

The paper identifies a fungal effector that enhances RPW8.2 nuclear localization and transcription, boosting immunity in Arabidopsis against powdery mildew.

The paper introduces PRM-SRS imaging to visualize and identify multiple lipid species in cells and tissues with high chemical specificity and subcellular resolution.

This paper introduces a microwave split-ring resonator that enables submillimeter precision neuromodulation by enhancing microwave field localization and efficiency for inhibiting neurons.

This study evaluates rVSV-based vaccines against SARS-CoV-2 variants, showing potent neutralizing antibodies and CD8+ T cell responses across multiple variants.

This study shows that loss of type I interferon signaling in neonatal mice reduces immature blood progenitors but has minimal impact on postnatal hematopoiesis.

The paper identifies an intervening network of tubulin-tau complexes that cross-link microtubules into bundles, revealing a new role for tubulin in stabilizing MT fascicles and preventing tau leakage in neurodegeneration.

The paper determines the structure of the PulL-PulM heterodimer in the T2SS assembly platform and proposes a model for its dynamic role in pseudopilus polymerization.

This study reports cryo-EM structures of Omicron subvariant S proteins, revealing conformational differences linked to transmissibility and immune evasion.

This study shows that kynurenic acid reduces A1 astrocyte activation and promotes A2 astrocyte formation, improving cognitive deficits in HIV-1 gp120 transgenic mice.

REST is a deep learning method that restores cryo-ET density maps by denoising and compensating for missing wedge effects, enabling visualization of individual macromolecules.

This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.

The paper introduces a method to detect and analyze i6A-modified RNA with single-base resolution using iodine-mediated oxidation and reverse transcription.