Y. Tang

This study investigates how β-ecdysterone affects fracture healing by modulating autophagy via the PI3K/AKT/mTOR pathway in osteoblasts.

This study identifies dipeptides as minimalistic yet sufficient for liquid-liquid phase separation through computational and experimental methods.

This study uses mass cytometry to analyze immunological changes in mice after radiation-induced cardiac fibrosis, finding increased macrophages and pro-fibrotic cytokines.

This study analyzes nasopharyngeal samples from COVID-19 patients and healthy controls to identify how SARS-CoV-2 infection affects respiratory epithelial cells and immune responses, finding impaired local intrinsic immunity in severe cases.

This study shows that loss of Rab35 or Arf5 in glioblastoma cells increases tumor growth and invasiveness by activating the epidermal growth factor receptor and upregulating SPOCD1.

This study compares 15 fish species to identify genomic signatures of alkaline adaptation in both highland and lowland fish, finding consistent patterns of accelerated evolution and positive selection in shared genes.

This study identifies immune mechanisms underlying CyHV-3 resistance in a common carp strain through transcriptomic analysis of gene and lncRNA expression.

This study shows that KAI2a and KAI2b in Lotus japonicus have divergent ligand-binding specificities and organ-dependent redundancy in response to karrikin ligands.

This paper improves ELISPOT assay sensitivity for detecting neoantigen-specific T cells by co-stimulating with anti-CD28 and IL-2, increasing detection by up to 5-fold.

HiFi-SIM improves structured illumination microscopy image fidelity by reducing artifacts and enhancing axial resolution without requiring precise PSF calibration or parameter tuning.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This study shows that S100A9 promotes neural stem cell differentiation and inhibits their stemness, suggesting a role in neurodegenerative disease progression.

The paper identifies AMR4, a CaaX-like protease in Plasmodium parasites, which is essential for apicoplast biogenesis but does not function in the expected CaaX post-prenylation pathway.

This study models antibody-target binding dynamics in tumors using BRET imaging and finds spatial differences in cetuximab binding to EGFR.

This study introduces a quantitative metric to evaluate therapeutic antibody doses and identifies factors influencing dose selection beyond traditional pharmacokinetics and target binding affinity.

This paper investigates the ligand recognition mechanism of PHF20L1 Tudor1, revealing a pre-existing open conformation that enables binding to both methylated proteins and small molecules.

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

This paper introduces a novel class of self-assembling dsRNA therapeutics that target specific oncogenic sequences and induce apoptosis in cancer cells.

This study examines the effects of dietary Citrus reticulata 'Chachi' products on the fecal microbiome of weaned piglets using multi-omics analyses, showing changes in microbial diversity, SCFAs, and proteomic profiles.

This study investigates the effects of human umbilical cord mesenchymal stem cell transplantation on preserving and restoring fertility in aging and chemotherapy-damaged female mice.

This study reviews scientific research on farmers' roles in agricultural adaptation to climate change from 2008-2017, finding limited global representation and methodological diversity.

This paper develops an anti-MUC1 antibody-drug conjugate targeting a GSTA glycosite-signature epitope, showing potent antitumoral efficacy and low toxicity in NSCLC models.

This study uses machine learning to predict TCM Meridians based on molecular features of herb compounds, achieving 83% accuracy.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.

This study characterizes the NF-κB protein in the sponge Amphimedon queenslandica, showing conserved features with vertebrates but distinct regulatory mechanisms.

This study shows lung cancer exosomes promote MDSC expansion via miR-21a/PDCD4/IL-6/STAT3 pathway, enhancing tumor growth.

This study shows that LSD1, recruited by Blimp-1, represses PD-1 expression during acute infection by removing activating histone marks and is necessary for remethylation of the Pdcd1 locus.

The paper identifies an NRPS-like enzyme in fungi that catalyzes the reductive conversion of glycine betaine to choline, revealing its role in choline biosynthesis and homeostasis.

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.