Y. Wu

This study investigates how ATP hydrolysis by MDA5 and LGP2 influences viral RNA sensing, showing MDA5's selectivity and LGP2's role in modulating MDA5 filament assembly.

The paper identifies eIF3k as a regulator of ribosome content in cancer by showing its depletion increases global translation and stress resistance through repression of RPS15A synthesis.

This study introduces DeepT2, a machine learning model that predicts type II polyketides from KS{beta} sequences without alignment, using NLP techniques and metagenomics/metabolomics data.

This study identifies Xosr001, an sRNA packaged in OMVs of Xoc, as a mediator of stomatal immunity in rice by modulating OsJMT1 and MeJA levels.

This paper introduces a computational framework using spatio-temporal atlases to establish normative trends in perinatal structural brain connectivity from diffusion MRI data.

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

This study identifies RNA sensing and innate immunity in host embryos as a barrier to interspecies chimerism and shows that modifying host embryos can enhance human cell survival in chimeric embryos.

This paper introduces a self-healing PDMS material with safety-enhancing properties for wireless, skin-interfaced bioelectronic devices.

The paper characterizes the Kiwa defence system as a bacterial membrane supercomplex that detects phage-induced membrane changes and inhibits phage replication.

The paper identifies a stress-response gene network linked to CD1C-CD141 dendritic cells that correlates with prognosis in burns and COVID-19.

This study identifies unique features of long-lived plasma cells (LLPCs), including reduced motility, clustering, and specific surface markers, and shows that CXCR4 is critical for their survival and antibody production.

The paper designs transmembrane proteins that inhibit the erythropoietin receptor by competing with homodimerization in a custom binding topology.

This study identifies ULK1/2 as regulators of PXN-dependent mechanotransduction in breast cancer cells, showing their role in inhibiting migration by modulating focal adhesion assembly.

This study investigates the effects of near-complete Myc inactivation in mice, finding premature aging features but reduced cancer incidence and linking Myc dysregulation to aging and cancer.

The paper establishes the EstroGene database, which compiles 246 experiments from 136 datasets to analyze estrogen receptor regulomes in breast cancer, revealing diverse temporal, context-dependent, and directional responses.

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

This study characterizes human glioblastoma organoids using multi-omics analysis and identifies drug targets linked to glycerol lipid reprogramming.

This study develops a novel rat neuroblastoma model to evaluate surgical treatments, showing tumor growth and feasibility of resection.

The paper determines in situ structures of GspD and GspDβ secretins during translocation, revealing distinct membrane interaction patterns and translocation mechanisms.

This paper introduces KiMBIs, bioluminescent indicators that enable non-invasive imaging of kinase inhibitor activity in the brain, identifying temuterkib as a promising brain-active ERK inhibitor.

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

This study shows that PXN phase separation drives focal adhesion assembly and integrin signaling through light-inducible manipulation.

The paper analyzes RNA-seq and scRNA-seq datasets to identify immune cell interactions in the testicular microenvironment of azoospermia patients, finding altered monocyte/macrophage signaling patterns.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This paper develops a magnetic bead-based PEA (SP-PEA) for sensitive protein and extracellular vesicle detection in plasma and serum, showing 15-60 fold increased sensitivity compared to solution phase PEA.

This paper introduces an Odourgenetic method using Drosophila odorant receptors to non-invasively and rapidly manipulate cellular functions and behavior through inhalation of 2-pentanone.

This study develops a method using minicircle DNA to rapidly generate CD19 CAR-T cells that are effective and safe, avoiding genomic integration risks.

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

The paper estimates the genetic diversity of viruses using simulated discovery processes, finding that less than 3% of viral genetic diversity has been uncovered.

The paper shows that P2Y2R signals, via Gq and increased [Ca2+]i, transactivate allosterically modulated FFA2R, revealing a unique cross-talk mechanism between GPCRs.