Y. Wu

This study shows that cardiomyocytes and noncardiomyocytes respond differently to starvation, with cardiomyocytes showing unstable autophagic activity and greater vulnerability to nutrient deprivation.

This study uses single-cell RNA sequencing to show that aged alveolar macrophages exhibit a senescence-like phenotype linked to reduced CBFβ expression and impaired self-renewal.

This study analyzes the spatiotemporal patterns of scrub typhus in China from 2012 to 2018, identifying key meteorological, environmental, and socio-economic factors influencing its distribution.

This study develops Nm-VAQ, a qPCR-based method to precisely validate and quantify RNA 2'-O-methylation sites, demonstrating its application on rRNA.

This study identifies self-organized canals in bacterial colonies that enable long-range directed transport of cells and vesicles, driven by biosurfactant-mediated fluid flows.

This study shows exogenous DNA activates the cGAS-STING pathway in pancreatic cancer cells, increasing DUOX2 expression and H2O2 production, which may promote an oxidative microenvironment.

The paper identifies kinesin adaptors that mediate spectrin transport and lattice expansion during axon stretch-growth.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

This study shows that VPS13A and XK interact at ER-PM contacts, with VPS13A's PH domain binding XK, and suggests this interaction may link lipid transfer to PM lipid scrambling, potentially contributing to neurodegeneration.

This study shows that Pseudomonas aeruginosa releases volatile hydrogen cyanide (HCN) that inhibits Staphylococcus aureus growth in low oxygen environments, providing a competitive advantage in biofilms and in vivo lung infections.

This study maps single-cell transcriptomes and T cell repertoires in Behcet's disease to identify immune mechanisms and T cell trajectories in vascular and dermal manifestations.

This study shows hyperuricemia induces renal tubular epithelial pyroptosis via ROS-mediated NLRP3 inflammasome activation in cultured cells and rat models.

This study shows that reducing SERCA2 in adipocytes impairs metabolic function, with white adipose tissue showing increased glucose uptake and brown adipose tissue showing reduced mitochondrial function.

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.

The paper presents the first in situ evidence for a bridge-like structure of VPS13C at ER-lysosome contacts, supporting its role in lipid transport.

This paper introduces RLN, a deep learning method for 3D fluorescence microscopy deconvolution that improves speed, performance, and generalizability compared to existing methods.

This paper reports chromosome-level genome assemblies of five Sitopsis species and identifies the B-subgenome donor of bread wheat as an extinct species closely related to Ae. speltoides.

This study investigates how reducing chemical fertilizers and adding bio-organic fertilizer affects soil microbial communities and Baby Chinese cabbage yield in Gansu plateau, finding that T2 treatment yields the highest crop output.

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

This study shows that nitric oxide signaling via the sGC/cGMP pathway controls collective contractions in the colonial choanoflagellate Choanoeca flexa, similar to its role in early animals.

This study identifies tRNA thiolation as essential for plant immunity by showing its role in regulating NPR1 translation and salicylic acid signaling in Arabidopsis.

This study shows dexamethasone inhibits cytokine-induced DUOX2 and VEGF-A expression and DNA damage in pancreatic cancer cells and xenografts, but not in cytokine-unresponsive cells.

This study identifies LspA as a key factor in hGIIA resistance in MRSA and shows that inhibiting LspA increases susceptibility to hGIIA and daptomycin.

This paper develops a bioluminescence-activated PDT system that eradicates tumors and prevents metastasis in mice by using efficient BRET conjugates and membrane-fusion liposomes.

This study reports the structure of the MCM8/9 helicase complex using cryo-EM, revealing its DNA unwinding mechanism through conformational changes and rotary motions.

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

This study identifies BOS1 as a positive regulator of wounding-induced cell death and plant susceptibility to Botrytis cinerea, showing its role in both fertility and disease response.

This study identifies BDSF as a degradation-prone quorum-sensing signal in Xanthomonas campestris pv. campestris, detected by RpfC, with lower physiological activity than DSF due to RpfB-mediated degradation.

The paper identifies a chloroplast envelope domain where translation occurs, supporting co-translational protein targeting in Chlamydomonas reinhardtii.