Z. Liu

The paper identifies CH25H and its product 25HC as inhibitors of SARS-CoV-2 replication by blocking membrane fusion.

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

This study shows that SARS-CoV-2 ORF3a induces incomplete autophagy by interacting with UVRAG, impairing autophagosome maturation and enhancing viral replication.

This study investigates how a dominant-negative SOX18 mutant disrupts transcription factor activity by interfering with chromatin-binding dynamics and recruiting the wild-type interactome.

The paper genetically modifies SARS-CoV-2 RBD variants in yeast to identify a more stable and manufacturable vaccine candidate.

This study investigates TRPM2's role in pancreatic cancer, finding it promotes proliferation, migration, and invasion through the PKC/MAPK pathway.

This study develops a yeast-expressed SARS-CoV-2 RBD protein vaccine candidate, RBD219-N1C1, which induces neutralizing antibodies and T-cell responses in mice.

Two diketopiperazines (DKPs) produced by sporulating Bacillus thuringiensis stimulate diatom P. tricornutum growth and increase lipid content.

This paper uses an agent-based model to show that holobionts with horizontal microbial symbiont transmission can adapt to increasing abiotic stress through symbiont adaptation, depending on host-symbiont recognition abilities.

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

This study uses Hi-C to identify structural variations in lung adenocarcinoma tissues, revealing compartment shifts, TADs, and enhancer-promoter loops associated with key genes on chromosome 3.

This study shows that intestinal microbiota modulates epinephrine storage and secretion in adrenal chromaffin cells via Nod1 sensing of bacterial ligands during stress.

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

This study develops new DSRCT models and shows that targeting the ERBB pathway with EGFR inhibitors reduces tumor growth in preclinical models.

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

This study shows telmisartan enhances insulin secretion via ion channels, independent of AT1 receptor and PPARγ, in rat islets and diabetic mice.

DyRAST uses dynamic laser speckle imaging and machine learning to rapidly predict antibiotic minimum inhibitory concentrations in E. coli within 60 minutes.

This study examines metabolomic changes in the heart during chronic T. cruzi infection, linking metabolic alterations to cardiac fibrosis and inflammation.

The paper predicts range contractions of 48 endemic birds in the Cordillera de Talamanca under climate change scenarios, with greater declines under severe scenarios.

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

This study identifies CECR2 as a driver of breast cancer metastasis by suppressing macrophage inflammatory responses, offering a therapeutic target for metastatic disease.

This study maps mutations in the SARS-CoV-2 spike RBD that escape antibody recognition, revealing escape mutation patterns and enabling the design of antibody cocktails.

The paper uses single-molecule imaging to study RAG recombinase dynamics in live pro-B cells, revealing its search strategy for chromatin and the IgH locus.

This study shows that genome doubling in allopolyploids can recover transcriptional and splicing changes from hybridization, partially fixing heterosis and revealing new insights into transcriptome reprogramming mechanisms.

The paper identifies a catch bond mechanism in a bacterial adhesion complex that resists high shear forces in the human gut.

This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.

This study shows that deuteration of small-molecule fluorophores enhances their brightness, chromostability, and photostability in cellular imaging.

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

This study identifies Bmp8a as a positive regulator of antiviral immunity, showing its role in enhancing type I IFN production and reducing viral load in zebrafish.