Z. Zhang

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

This study shows DDX5 resolves a G-quadruplex in STAT1 mRNA 5UTR, enabling STAT1 translation and interferon signaling in HBV-infected hepatocytes.

This study shows that inactivating ATPIF1 enhances CD8+ T cell antitumor activity by reprogramming their metabolism, leading to better tumor suppression in mouse models.

This study shows that combining free ammonia pretreatment with anaerobic digestion reduces antibiotic resistance gene abundances in sludge.

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

This study identifies PFKM as a direct target of celastrol, showing that its inhibition promotes weight loss and leptin sensitivity through AMPK/ACC signaling.

This study induces bipedal posture in mice to create a model of lumbar ligamentum flavum hypertrophy and shows increased stress leads to degeneration.

The paper analyzes mutation spectra and compositional variability in SARS-CoV-2 clades to understand mutation patterns and their implications for viral proteomes.

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

This study identifies TMEM39 as a conserved ER protein that facilitates collagen secretion and prevents ER stress by interacting with COPII components.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

This study shows dietary propionate causes intestinal oxidative stress in zebrafish by inhibiting SIRT3-mediated SOD2 depropionylation, leading to gut microbiota changes.

The paper develops new fluorogenic probes for live-cell and super-resolution microscopy with minimal label size and efficient quenching.

This study shows that changes in plasma cfDNA levels during chemotherapy predict clinical response in NSCLC patients, with specific insights for lung adenocarcinoma.

This study identifies POR and CYB5R1 as oxidoreductases that generate hydrogen peroxide, driving iron-dependent lipid peroxidation and ferroptosis.

This study identifies a Vitamin D-driven mechanism that suppresses excessive Th1 responses in COVID-19, suggesting potential therapeutic use of Vitamin D analogs.

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

This study investigates how structural and dynamic features of the N-terminal domains of connexin 46 and 50 influence gap junction channel stability and conductance through molecular dynamics simulations and electrophysiology.

The paper investigates how direct energy transfer from photosystem II to photosystem I helps Scots pine survive winter by enabling sustained quenching and photoprotection.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

The paper creates a single nucleus multi-omics atlas of the murine pituitary, revealing cell type-specific regulatory mechanisms and identifying a cis-regulatory region linked to fertility.

This study introduces a new bioprinting method using a yield-stress granular gel to position and assemble tissue spheroids in 3D for cartilage and bone tissue construction.

This paper describes the design of a fusion protein using human ferritin to present the SARS-CoV-2 spike glycoprotein RBM, suggesting it as a potential vaccine candidate.

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

This study identifies FSTL1-expressing adipocyte progenitors as drivers of age-related brown adipose tissue involution in rabbits and humans, with loss of FSTL1 causing iBAT atrophy in mice.

This study quantitatively synthesizes allelopathic effects across 385 studies, finding a 25% reduction in plant performance and variation influenced by method type, study duration, and phylogenetic distance.

The paper introduces a method to label subcellular structures in living specimens using live-cell incompatible dyes under specific conditions, revealing their potential for imaging.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.