F. Chen

This study shows IFITM3 restricts CHIKV and MAYV infection and is counteracted by these viruses, with a variant showing similar antiviral activity to wild-type.

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.

The paper uses single-cell RNA sequencing to identify early transcriptional changes in kidney cells after podocyte injury, revealing disrupted cell-cell interactions that contribute to chronic kidney disease progression.

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

The paper investigates the ability of Arhopalus rusticus to transmit pine wood nematodes, finding that 12 beetles can transmit the nematodes through feeding on pine needles.

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.

This paper develops an in vivo protein kinase analysis method using chemical genetics and nanoparticle-mediated ATP analog delivery, demonstrating its applicability to AKT1.

This study compares non-Cochrane nursing systematic reviews with their PROSPERO-registered protocols, finding widespread discrepancies with few explanations.

The paper uses imaging techniques to show that splicing occurs in a slow-moving zone near the transcription site, suggesting a model where splicing is post-transcriptional but occurs close to transcription.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

This paper identifies elasnin as a potent antibiofilm agent that inhibits mono- and multi-species biofilms with low toxicity and resistance risk.

This study profiles the 2-hydroxyisobutyrylome in common wheat, identifying Khib modification sites and their roles in metabolic pathways and enzyme regulation.

The paper investigates the role of pcyt-1 gene expression in pine wood nematode departure from its beetle vector, finding that up-regulation of pcyt-1 promotes lipid degradation and motility necessary for departure.

The paper uses single-cell RNA sequencing to compare transcriptional heterogeneity between invasive ductal and lobular breast cancer cell lines, identifying CDH1 loss effects and potential mediators of ILC-specific features.

This study shows hypercapnia suppresses macrophage antiviral activity and increases influenza A mortality via Akt1 activation in mice.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

This study isolates and characterizes ten novel pelagiphages infecting Pelagibacter strains, revealing their genetic diversity, global distribution, and ecological significance.

This study investigates how the feeding behavior of Monochamus alternatus affects the departure of pine wood nematodes, finding no significant difference but linking increased motility and oxidative phosphorylation to nematode departure.

The paper tests how changes in geomagnetic field intensity affect migration-related traits in the brown planthopper, finding responses in morphology, behavior, and physiology.

This study shows that absence of geomagnetic field reduces feeding in brown planthopper nymphs, leading to lower body weight and altered glucose levels and appetite-related gene expression.

The paper isolates and characterizes seven phages infecting Roseobacter RCA lineage bacteria, revealing genomic diversity and abundance in marine virosphere.

This study uses single-cell RNA-seq to analyze human infant retina, identifying cell types, communication networks, and developmental changes, providing a resource for retinal research and regenerative medicine.

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

This paper develops a CRISPR-Cas13b-based tool to specifically demethylate m6A modifications on target mRNAs, enhancing their stability and demonstrating efficient gene regulation with minimal off-target effects.

This study identifies miRNA-138 as a negative regulator of HIF1α, showing its ability to suppress melanoma growth and metastasis through direct targeting of HIF1.

This study investigates the fracture behavior of defective popgraphene using molecular dynamics and continuum modeling, revealing how different defect types affect fracture stress.

This study examines how elevated CO2 affects the development and food utilization of Mythimna separata larvae feeding on Bt maize infected with nitrogen-fixing bacteria.