H. Liu

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

This paper investigates the increased transmissibility of the SARS-CoV-2 501Y.V1 variant due to the N501Y mutation in the Spike protein's RBD and its impact on ACE2 binding and vaccine efficacy.

This study shows that inhaled anesthetics reduce neural excitability by disrupting multiple-water entanglement networks, which amplify hydroxide ion concentration changes.

This study identifies a novel folliculogenesis and follicular placentation mechanism in black rockfish, highlighting hormonal changes and conserved genes in placental development.

This study identifies SlBES1 as a regulator of tomato fruit softening by repressing PMEU1, leading to firmer fruits with extended shelf life without affecting visual or nutritional quality.

This study shows that heterozygous Vegfr3 mutation reduces renal lymphatics but does not impair renal function or histology, even after cisplatin injury.

This study identifies ISG20 as a key antiviral factor against Zika virus in trophoblast cells and demonstrates the therapeutic potential of recombinant ISG20-Fc protein.

This study describes a 370-day closed artificial ecosystem experiment to test bioregenerative life support systems for long-term lunar habitation, demonstrating high material closure and system stability.

This study uses fMRI to show that amblyopia causes layer-specific changes in subcortical visual pathways, with reduced feedforward signals in the geniculostriate pathway and altered feedback signals in the retinotectal pathway.

The paper identifies binary and ternary protein interactions among SARS-CoV-2 replication/transcription complex components using a novel compartmentalization-based screening method.

The paper identifies two transcription factors, RlmA and Ace1, critical for Aspergillus fumigatus virulence by analyzing gene expression during lung infection in mice.

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

The paper identifies celastrol as a novel HIV-1 latency reversal agent through an image-based screen of a natural compound library.

The paper systematically investigates dynamic mechanical stimulation protocols for mesenchymal stromal cells to optimize matrix production and myofibrogenesis in 3D hydrogels.

The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.

This study shows that disrupting FGF2 enhances thermogenesis in brown and beige fat, reducing obesity and hepatic steatosis in mice.

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

This study shows that deleting Letmd1 in mice causes mitochondrial dysfunction in brown adipose tissue, leading to thermogenesis disruption and metabolic disorders.

The paper analyzes public data to show that PDCD1 and CD274 expression in T cells and macrophages correlates with COVID-19 severity.

This study investigates how a dominant-negative SOX18 mutant disrupts transcription factor activity by interfering with chromatin-binding dynamics and recruiting the wild-type interactome.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

This study shows that cannabidiol (CBD) reduces pulmonary arterial hypertension by improving mitochondrial function and reducing oxidative stress in vascular smooth muscle cells.

This study uses directed evolution to identify SH2 domain variants with enhanced binding to phosphotyrosine peptides, revealing differences in cross-reactivity with sulfotyrosine.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

This study identifies SARS-CoV-2 papain-like protease (PLpro) as a novel substrate of ULK1, demonstrating its role in disrupting host autophagy to promote viral replication.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

The paper constructs and validates a prognostic signature for prostate cancer using ferroptosis-related genes, showing its association with clinical outcomes and therapeutic response.

This study uses respiratory tract explants from marine mammals and rhesus macaques to compare influenza A virus infection kinetics across species.