H. Ma

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study develops an AI-driven multi-resolution simulation workflow to study SARS-CoV-2 RTC dynamics, combining cryo-EM with mesoscale simulations and AI methods.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

The paper quantifies global trait variation in trees, identifying two independent processes and seven key traits that capture most variation in tree form and function.

This study identifies a tick metabolic pathway involving ISARL that Borrelia burgdorferi exploits to establish infection, suggesting a mechanism for manipulating host metabolism.

This study shows that VEEV persists in the CNS of macaques long after acute infection, with ongoing inflammation and immune cell infiltration.

This paper develops a deep learning model to classify red blood cell deformability from single-cell microscope images, achieving high accuracy comparable to specialized equipment.

This study measures RBC deformability loss during cold storage and finds donor-dependent variations, particularly accelerated loss in male donors beyond 42 days.

This study shows that RBCs sampled from blood unit segments accurately reflect biophysical properties of RBCs in blood bags but not hemolysis over 8 weeks of storage at 4°C.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.

The paper develops a sensitive and specific real-time PCR assay for detecting novel-goose parvovirus in vitro and in vivo, showing high sensitivity and reproducibility.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

This study shows eosinophils are recruited to tuberculosis-infected lung tissue in mice and contribute to host resistance against Mtb infection.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study identifies the roles of histone acetyltransferases and deacetylases in the growth, virulence, stress resistance, and DNA repair of Alternaria alternata through gene deletion mutants.

This paper develops and characterizes SARS-CoV-2 RBD-specific alpaca nanobodies, showing improved binding affinity and neutralizing potency through bivalent engineering.

The paper develops an automated classifier to detect Hainan gibbon calls using deep learning, achieving high accuracy and reducing manual processing time.

The paper compares ligand-binding sites of Mpro proteases from SARS-CoV2, SARS-CoV, and MERS-CoV using deep learning and Markov state models to assess structural dynamics and conservation.

This paper identifies a novel non-covalent inhibitor of SARS-CoV-2 main protease through high throughput virtual screening, validated by biochemical assays, X-ray crystallography, and molecular dynamics simulations.

This study links genomic changes like WGD and gene duplication to phenotypic innovation and diversification in gymnosperms, showing ecological factors also drive diversification after angiosperms.

The paper investigates syncytia formation between SARS-CoV-2 infected and ACE2-expressing cells, finding that it leads to pyroptosis via Caspase-9 and GSDME activation, contributing to severe COVID-19 inflammation.

The paper identifies hyperactive antibody responses and vascular pathology in metabolic-active lung tissues of tuberculosis patients, sharing features with autoimmune diseases.

This study identifies hnRNP K overexpression in AML and shows it causes myeloproliferative disease in mice by altering RUNX1 splicing.

This study compares knowledge and awareness of COVID-19 between Chinese dental students and nonmedical students, finding dental students scored higher overall but had weaknesses in treatment and prevention.

This study identifies exosomal miR-224's role in maintaining hemolymph microbiota homeostasis during bacterial infection in mud crabs by modulating immune signaling pathways.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

This paper develops an AI-driven workflow to simulate SARS-CoV-2 spike protein dynamics, revealing glycan shield structure, spike glycans' role in infectivity, and spike-ACE2 interactions.