S. Li

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

The paper reports the chemical structures of two cADPR isomers, their production mechanism, and their roles in antiviral signaling and plant immunity suppression.

This study evaluates the use of nanopore sequencing for SNP and cgMLST subtyping of Salmonella Enteritidis, showing high concordance with Illumina data despite sequencing errors.

The paper introduces the PDXNet Portal, a centralized resource for PDX models and data, offering analysis workflows and facilitating cancer research collaboration.

This paper describes a scalable method for producing high-quality recombinant three-finger proteins using E. coli, enabling their use as molecular probes.

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

This study identifies Hippo signaling pathway activation as an antiviral response to SARS-CoV-2 infection and shows pharmacological targeting of the pathway can reduce virus replication.

This study investigates how microbial response strategies vary with environmental change frequency in sulfidic stream microbiomes, finding that rapid changes favor stochasticity and bet-hedging, while slow changes benefit codon-usage bias.

The paper shows that phase-separated TRB proteins aggregate with PRC2 to enhance Polycomb silencing in plants.

This study shows that both tree species and genetic diversity increase productivity through functional diversity and trophic feedbacks, with genetic diversity effects varying between monocultures and mixtures.

This study sequenced S. Typhimurium strains from wild birds in the U.S. and identified three distinct lineages associated with different bird types, improving source attribution and outbreak investigation.

This paper develops P450-expressing Huh7 cell lines to generate xenobiotic metabolites, enabling high-throughput analysis of drug metabolism and identification of specific enzyme-substrate interactions.

This study identifies the dual role of AAGAB's tetramerization domain in stabilizing AAGAB and binding substrates during AP1/AP2 complex assembly.

The paper identifies monosynaptic inputs to parabrachial neurons projecting to the paraventricular nucleus of the thalamus, revealing their connectivity with brainstem and forebrain regions involved in arousal and homeostasis.

This study shows that an Omicron-matched DNA vaccine booster enhances cross-reactive immunity against Delta and Omicron variants in mice compared to an ancestral strain booster.

This study shows Bach2 negatively regulates NK cell maturation and function by correlating with TCF1 and opposing effector molecule and cell cycle gene expression.

This study identifies stage-specific microbial and metabolic changes in RA progression using multi-omics data from a cohort of patients.

This study shows that Sox2 forms DNA condensates that exert mechanical forces up to 7 pN, but chromatin nucleosomes reduce this force by sequestering Sox2.

This study constructs multiscale models of SARS-CoV-2 using coarse-grained molecular dynamics simulations and experimental data, revealing dynamic behavior of membrane proteins and lipid interactions.

This study characterizes the genomic basis of the plant island syndrome in Darwin's giant daisies by analyzing the genome of Scalesia atractyloides, identifying subgenomes, polyploidization events, and genes under selection.

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

This paper develops two new strategies for constructing large variant DMS libraries in mammalian cells using piggyBac-mediated genomic integration and in-vitro ligation.

The paper hosts a DREAM Challenge to evaluate computational models for predicting drug polypharmacology using perturbational profile data from 32 kinase inhibitors.

This paper shows engineered ACE2 neutralizes Omicron and other sarbecoviruses effectively despite its high number of spike mutations.

This study compares immune responses between BioNTech and Sinovac vaccines in Hong Kong, finding Sinovac induces lower neutralizing antibodies and wanes faster against SARS-CoV-2 variants.

This study identifies two snoRNA-derived fragments, sdRNA-D19b and sdRNA-A24, that promote castration-resistant prostate cancer by downregulating tumor suppressors and conferring drug resistance.

RNA2Immune is a database linking noncoding RNAs to immune functions, diseases, and vaccines, containing 50,433 experimentally supported associations across 42 species.

This study shows that atypical B cells actively respond to acute malaria and have the capacity to produce antibodies with T cell help.

This study shows dihydroartemisinin (DHA) enhances anti-PD-1 therapy in hepatocellular carcinoma by inhibiting YAP1 and disrupting immune evasion through PD-L1, JAK1/STAT1, and JAK3 pathways.