S. Li

This study shows that H2A.Z reduces the energy barrier for DNA unwrapping, increasing DNA accessibility and nucleosome mobility.

This study identifies Tmem100 as a lung-specific endothelial gene through single-cell RNA-sequencing analysis.

The paper identifies leader beta cells in pancreatic islets using Flash-Seq and finds they have a distinct transcriptome and localization compared to follower cells.

This study evaluates CRISPR/Cas9, CRISPR/LbCpf1, and base editors for targeted genome editing in grape, showing variable efficiencies and PAM specificity.

The paper introduces ELI-TriScope, a cryogenic system for precise cryo-lamella preparation, achieving 100% success in targeting HeLa cell centrosomes for cryo-ET structural analysis.

This paper designs, fabricates, and characterizes 3D RNA-scaffolded wireframe origami structures using different RNA sequences, revealing structural insights and demonstrating the potential for functional RNA scaffolds.

The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.

The paper identifies TRIM32 as a host E3 ubiquitin ligase that targets SseK3, an SPI-2 effector, to restrict Salmonella-induced filament biogenesis and replication.

The paper identifies novel viroid-like circular RNAs in a fungal host, showing they replicate autonomously and modulate host biology, suggesting a new class of viroid-like entities in fungi.

This paper investigates the roles of DHNA and riboflavin in extracellular electron transfer in Lactiplantibacillus plantarum, identifying distinct pathways for iron and anode reduction.

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

This study analyzes fecal metagenomes to identify viral signatures associated with colorectal cancer and adenoma, finding distinct virome patterns and developing predictive models with high accuracy.

This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.

This study identifies infection-enhancing antibodies in COVID-19 patients and healthy donors, finding they are more frequent in patients but also present in healthy individuals.

This study identifies cAMP as a key mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis by analyzing the role of the essential adenylate cyclase Rv3645.

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.

This study quantitatively maps yeast cell fate decisions in response to pheromone by integrating experimental observations with theoretical models and stochastic simulations.

This study identifies Arabidopsis AAR2 as a conserved splicing factor that also promotes miRNA biogenesis by interacting with HYL1 and regulating its dephosphorylation.

This study generates functional posterior spinal motor neurons from hPSCs-derived neural progenitor cells, demonstrating efficient differentiation and functional maturity.

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

This study identifies Nup170's role in subtelomeric gene silencing by regulating PCNA levels through the Ctf18-RFC complex and Mlp1/Mlp2-dependent NPC subpopulations.

The paper shows that actin filaments and membrane compression from synaptic vesicle exocytosis drive ultrafast endocytosis at synapses.

This study shows that the adipose-neural axis contributes to cardiac arrhythmias through leptin-induced activation of sympathetic neurons and subsequent effects on cardiomyocytes.

This study identifies MNX1 as a driver of t(7;12)(q36;p13) pediatric AML by altering histone methylation and shows that targeting MNX1 can prevent leukemia development.

The paper introduces asari, a new open-source tool for LC-MS metabolomics data processing that improves reproducibility, performance, and scalability.

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

This study identifies distinct immune ecosystems in true and de novo HBV-related HCC recurrences using single-cell and bulk RNA-sequencing, revealing differences in T cell phenotypes and immune interactions that may inform immunotherapy strategies.

The paper reanalyzes PANDORA-seq data to show 28s5-rtsRNA is abundant and functions with 5.8s rRNA-derived small RNA to reduce ribosomal protein mRNA levels, with key nucleotides identified through mutational scanning.

This paper designs a small molecule STING agonist, SNX281, using computational methods and AI, showing systemic activity and antitumor effects in mice.

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.