W. Liu

This study determines the crystal structure of AtMC4, revealing how Ca2+ activates plant metacaspase through linker domain cleavage and substrate access.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This paper identifies a dual activity in LanD-like flavoproteins for forming aminovinyl-cysteine residues through oxidative decarboxylation and cyclization of peptides.

The paper identifies essential residues in ATP11A for its expression and flippase activity through mutation analysis and functional assays.

This study identifies ZmEHD1's role in maize kernel development and growth by regulating auxin homeostasis through clathrin-mediated endocytosis.

The paper investigates the role of Hfq in Staphylococcus aureus pigmentation and finds that Hfq absence or accumulation does not affect carotenoid production or color.

This paper develops a method combining image registration and deep learning to automate landmark detection for geometric morphometrics, showing significant error reduction compared to manual methods.

The paper shows that stress-induced myonectin improves glucose homeostasis by inhibiting glycemic response to epinephrine and enhancing insulin sensitivity in adipose tissues.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

This paper identifies a long non-coding RNA, EDAL, that inhibits neurotropic viruses by promoting EZH2 degradation through O-GlcNAcylation site interference.

This study examines changes in IL-10 expression in myocardial infarction and its association with macrophage activation and cardiomyocyte apoptosis over time.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

This study demonstrates the use of modified LCP and MicroED protocols to determine structures from microcrystals embedded in LCP using proteinase K as a model system.

This study shows HIV-1 Nef interacts with LMP7 to reduce immunoproteasome formation and MHC-I antigen presentation, aiding viral immune evasion.

This study differentiates urine-derived induced pluripotent stem cells from a diabetic patient into neuron, astrocyte, and microvascular endothelial cells to create an in vitro disease model for studying diabetes-related CNS complications.

This study shows that GIGANTEA recruits UBP12 and UBP13 to the ZTL complex to stabilize clock proteins during the day.

This study uses single-cell analysis to evaluate antiviral therapeutics, revealing efficacy and insights into drug resistance evolution and viral lifecycle impact.

This study shows that the I232T SNP in FcγRIIB causes structural changes that reduce ligand binding, contributing to SLE pathogenesis.

This study shows ionomycin treatment rescues osteoporosis in HPP by restoring Ca2+ influx via ALPL-mediated L-type Ca2+ channel trafficking in BMSCs.

The paper uses decoy E3 ubiquitin ligases to identify new regulators of the plant circadian clock, showing redundancy in PUB59 and PUB60's role in gene splicing and circadian period control.

This paper introduces high-resolution light-field microscopy for live-cell imaging with subcellular resolution and fast volumetric acquisition.

This study identifies NudCL2 as a cochaperone that stabilizes cohesin subunits by modulating Hsp90 ATPase activity, preventing mitotic defects and sister chromatid separation.

This study identifies GlnR as a nitrogen regulator that directly represses the prpDBC operon involved in methylcitrate cycle in M. smegmatis, linking nitrogen metabolism to carbon metabolism and affecting bacterial growth and macrophage survival.

The paper investigates the two-step binding kinetics of tRNAGly by the glyQS T-box riboswitch and identifies structural elements that regulate each step.

The paper investigates SAM-SAM domain interactions in Eph receptors and identifies SAMD5 as a new binding partner, explaining disease-related mutations.

The paper identifies type-2 CD8+ T cells (Tc2) enriched in severe eosinophilic asthma and shows PGD2 and LTE4 drive their recruitment and activation, contributing to eosinophilia.

BaalChIP corrects allele-specific ChIP-seq analysis for copy number variation in cancer genomes, improving detection of regulatory variants.