W. Liu

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This paper investigates the catalytic mechanism of SznF, revealing an unusual N-nitrosation pathway involving electron shuttling without high-valent iron species.

This study shows Mer2 phase separation forms droplet-loop chromatin structures to enable diverse meiotic DSB formation.

This study shows ORMDL1 is upregulated in colorectal cancer and associated with better patient survival.

This paper develops data-informed strategies to design hydrolytic nanozymes with enhanced catalytic activity and broad substrate specificity.

This paper identifies a shared trans flavin-dependent assembly line for 2,2-bipyridine formation in caerulomycin and collismycin antibiotics, revealing sulfur fate differentiation through differential sulfhydryl group treatment.

This study shows that loss of Tmem30a in podocytes causes albuminuria and glomerulosclerosis in mice, with reduced TMEM30A expression observed in human podocytopathies.

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

The paper identifies a metabolic coincidence mechanism in Arabidopsis that controls winter photoperiodism, independent of the canonical CO/FT pathway.

This study investigates the dynamic conformational equilibrium of the dengue virus NS3pro-NS2B complex and shows that proteolytic activity correlates with the population of the closed conformation.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

The paper investigates the ftin gene's role in wheat under cold stress, finding it inhibits spike development through multiple pathways and phenotypic changes.

This study shows that inhibiting FATP2 in MDSCs reduces ROS and enhances anti-PD-L1 immunotherapy by improving T-cell function and reducing PD-L1 expression.

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

This paper reports an AviCys formation pathway in thioviridamide non-lanthipeptides that does not require lanthionine synthetase activity.

This study identifies miR-1 as a conserved microRNA in ticks that prolongs engorgement time and is differentially expressed across developmental stages.

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This paper introduces AquaDust, a hydrogel nanoreporter for in situ measurement of leaf water potential in plants, demonstrating its ability to detect water potential gradients and support hydraulic modeling.

The paper identifies a neuro-responsive subset of muscle stem cells that support neuromuscular junction integrity during aging and neurodegeneration.

This study develops a thermostable anti-EBOV IgY antibody that retains neutralizing activity for one year at 25°C and provides complete protection in a mouse model.

This study identifies S100β-expressing vascular stem cells that respond to hedgehog signaling and contribute to vascular lesion formation in atherosclerosis.

The paper introduces a method to label subcellular structures in living specimens using live-cell incompatible dyes under specific conditions, revealing their potential for imaging.

The paper withdraws its manuscript due to the need for further experiments to validate conclusions.

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

The paper identifies MTHFD1 as a target for broad antiviral therapy by screening bat cells with RNAi and CRISPR libraries against mumps and influenza viruses.

This study shows that maternal vitamin D deficiency increases obesity risk in male offspring by altering immune responses and adipose tissue inflammation.