X. Guo

This study evaluates the PK/PD of LYSC98 against Staphylococcus aureus in a murine model, identifying Cmax/MIC as the best predictor of efficacy.

The paper identifies a conserved CTL epitope in the SARS-CoV-2 spike protein that is compatible with most HLA alleles and suitable for evaluating CD8+ T cell responses.

The paper analyzes the transcriptome of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine to understand immune response mechanisms and vaccine effectiveness.

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

This study shows the Nrf2/Keap1 axis is activated by EIAV-Rev, leading to antiviral effects through two mechanisms: enhancing antioxidant defenses and inhibiting Rev-mediated RNA transport.

This study shows that removing PU.1 in adipocytes increases energy expenditure and improves metabolic syndrome in aging mice.

This study compares single-promoter and dual-promoter lentiviral vectors for CAR expression and cytotoxicity in engineered NK cells, finding that the single-promoter pCDHsp enhances expression and cytotoxicity.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

This study shows SAFA interacts with antiviral RNAs to open chromatin and enhance immune gene expression during viral infection.

This study examines the formation and dynamics of bacterial aggregates in Enterobacter cloacae, revealing a new mechanism of collective motility driven by density-dependent motility changes.

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

This paper introduces a general finite-element framework for the Virtual Fields Method to identify constitutive parameters in nonlinear elasticity using measured deformation fields.

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

This study identifies renalase (RNLS) as a biomarker in pancreatic ductal adenocarcinoma (PDAC), showing elevated tissue and plasma levels correlate with worse tumor characteristics and reduced survival.

The paper identifies Catsup as essential for border cell migration by preventing ER stress and shows that zinc transport is critical for this process.

This study shows that the oral microbiota is transmitted through contact and shared environment, not host genetics, by comparing biological and adoptive mother-child pairs.

The paper develops a D-2-hydroxyglutarate biosensor using DhdR, which detects D-2-HG in biological samples with high specificity and sensitivity.

The paper reports on a DREAM Challenge to predict multi-target kinase inhibitors for RET-based tumors and Tauopathy, using neural network-based machine learning approaches.

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

This study identifies BRD2 as a regulator of ACE2 transcription and shows that BRD2 inhibitors block SARS-CoV-2 infection in human cells and animal models.

This study shows DUSP7 regulates ERK2 activity to ensure proper chromosome alignment during cell division, preventing aneuploidy and tumorigenesis.

This study uses hyperspectral imaging and machine learning to estimate glucosinolate levels in broccoli, aiming to detect postharvest senescence and improve freshness assessment.

This study shows that SR-A1 facilitates Leptospira phagocytosis by macrophages but also promotes bacterial dissemination and inflammation, worsening leptospirosis in mice.

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

This paper characterizes bacteriophage JD419, which has a broad host range and retains lytic activity under various conditions, and reports its genome lacking virulence or antibiotic resistance genes.

This paper introduces PlantU-net, an end-to-end segmentation network for maize seedling phenotyping from top-view images, achieving high accuracy with minimal training data.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

The paper introduces a framework to quantify microbial community assembly mechanisms in grassland soils under warming, finding homogeneous selection and drift dominate, with warming altering their relative contributions.