X. Lu

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

This study examines SARS-CoV-2 neutralizing and infection-enhancing antibodies, showing in vitro enhancement does not always lead to in vivo disease enhancement, but can cause increased lung inflammation in monkeys.

This study identifies GajA as a nucleotide-regulated endonuclease from the Gabija bacterial defense system, which is inhibited by NTP and dNTP but activated during phage infection.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This study shows that deleting Letmd1 in mice causes mitochondrial dysfunction in brown adipose tissue, leading to thermogenesis disruption and metabolic disorders.

The paper identifies acrylamide fragments that covalently inhibit EV71 3Cpro and SARS-CoV-2 Mpro by targeting their active site cysteine, inducing conformational changes and allosteric effects.

This study shows that cannabidiol (CBD) reduces pulmonary arterial hypertension by improving mitochondrial function and reducing oxidative stress in vascular smooth muscle cells.

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

This study classifies bladder cancer patients into immune and non-immune groups using NMF and NTP algorithms, finding immune-activated patients respond better to anti-PD-1 therapy.

The paper analyzes SARS-CoV-2 genome sequences to study mutation patterns and evolutionary dynamics, identifying mutations that may enhance viral fitness and provide insights for vaccine development.

The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.

This study identifies a conserved horseshoe-shaped region in the nsp5 protease interdomain loop of MHV that is essential for viral replication and may serve as a new drug target.

The paper identifies IL6 trans-signaling as a mechanism supporting DCC survival and outgrowth during clinical latency, with microenvironmental dependencies and PIK3CA mutations linked to metastatic progression.

This study identifies an immune class in prostate cancer associated with better recurrence-free survival and response to anti-PD-1/PD-L1 immunotherapy.

This study shows remdesivir effectively inhibits SARS-CoV-2 in human cells and mice, reducing viral load and improving lung function.

The paper identifies hypoxia response regulatory elements using ATAC-seq data from epithelial cells under hypoxia treatment and characterizes their genomic features and transcription factor enrichment.

This study shows that the coronavirus proofreading exoribonuclease nsp14-ExoN is essential for RNA recombination and generates defective viral genomes.

This study identifies three groups of direct repeats in Anabaena sp. PCC 7120 by analyzing the specificities of two Cas6 endonucleases, showing cross-recognition and functional coordination in CRISPR-Cas systems.

This study compares the secretome of Magnaporthe oryzae wild type and Δalg3 mutants, identifying 51 proteins requiring ALG3 for secretion and showing their roles in virulence and cell wall integrity.

The paper characterizes site-specific N-glycosylation of SARS-CoV-2 spike proteins expressed in human and insect cells, revealing differences in glycan types and their implications for infection and vaccine development.

This study identifies MeSSII's role in cassava starch biosynthesis by forming protein complexes with other enzymes, affecting amylose and amylopectin synthesis.

The paper isolates and characterizes SARS-CoV-2 from the first US COVID-19 patient, showing high replication in Vero cells and depositing the strain for public use.

This study applies r- and K-selection to HeLa cells to show how life history strategies influence tumor functional diversity through gene expression and ecological competition.

Marizomib inhibits primary tumor growth and reduces lung and brain metastases in pre-clinical triple-negative breast cancer models.

The paper identifies deamidation at Asn-358 in moxetumomab pasudotox causing conformational changes and reduced immunotoxin activity.

This study uses single-cell profiling to identify immunosuppressive cells in CDK4/6 inhibitor-resistant HER2+ breast cancer and shows that combinatorial immunotherapy can overcome resistance.

The paper identifies the ERF109-MYB51-MYC3 ternary complex as a regulator of jasmonate-induced indolic glucosinolate biosynthesis.

This study identifies GUARDIN as a key regulator of cellular senescence through a LRP130-PGC1α-FOXO4-p21 signaling axis and shows its role in enhancing rapamycin's anti-senolytic effects.

This study evaluates how golden apple snail residues affect soil properties and bacterial communities, finding that they increase soil nutrients and alter bacterial diversity and composition.

This study conducts a histone acetylome-wide association study (HAWAS) of tuberculosis, identifying differentially acetylated loci and their association with immune phenotypes.