X. Lu

This study shows marine picocyanobacteria utilize chitin, linking their planktonic lifestyle evolution to chitin degradation and ecological expansion.

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

The paper identifies Alr3614 as a repressor of type V-K CRISPR-associated transposase systems in Anabaena sp. PCC 7120 through genetic and structural analyses.

This study determines cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike and compares them to BA.1, revealing structural changes and immune evasion mechanisms.

This study evaluates the impact of R328 mutations on NGLY1 activity using an in vitro assay, identifying dysfunctional, similar, and decreased activity mutations.

This study edits the MeSWEET10a promoter in cassava to confer resistance to bacterial blight without affecting yield traits.

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

This study assesses the antiviral activity of remdesivir and GS-441524 against multiple SARS-CoV-2 variants, finding they remain effective against Delta, Omicron, and other variants.

This paper presents the first phylogenetic analysis of the subfamily Aceratheriinae, reclassifying tribes and identifying early diverging taxa based on morphological characteristics.

This study identifies distinct mutations in SARS-CoV-2's RdRp that confer remdesivir resistance, showing their biochemical mechanisms and transferability to other coronaviruses.

This study uses single-cell RNA sequencing to analyze cardiac immune cell dynamics after myocardial infarction in mice, identifying key immune subsets and their roles in disease progression.

This paper analyzes the evolution of SARS-CoV-2 through multiple strain waves, showing increasing mutations and suggesting a feedback loop between viral population size and mutation accumulation leading to the Delta strain.

RNA2Immune is a database linking noncoding RNAs to immune functions, diseases, and vaccines, containing 50,433 experimentally supported associations across 42 species.

This paper identifies PsFYVE1, a novel effector from Phytophthora sojae, which modulates plant immunity by altering transcription and alternative splicing of immunity-related genes through interaction with host RNA-binding proteins.

This study identifies Nrf2/FAM134B-mediated ER-phagy as a protective mechanism against oxidative damage in intervertebral disc degeneration.

The paper develops a causal framework to identify tumor-specific intercellular communication networks in head and neck squamous cell carcinoma, revealing subtype-specific patterns linked to clinical outcomes.

This paper isolates and characterizes five sterols from Laminaria japonica and evaluates their anti-inflammatory and antioxidant activities through enzyme inhibition and molecular docking.

This study identifies HOXB13's AR-independent role in suppressing lipogenesis via HDAC3-mediated epigenetic repression, linking its loss to metastatic prostate cancer progression.

This study identifies a ZBP1-RIPK1-RIPK3 pathway that promotes SARS-CoV-2-induced cytokine expression through inflammatory signaling independent of cell death.

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

The paper develops a framework to quantify DOM-microbe associations under global change, finding that molecular traits and nutrient enrichment influence these interactions differently in subarctic and subtropical climates.

This study shows that nucleoside-modified mRNA can encode HIV-1 Env trimer nanoparticles that induce bnAb precursor B cell expansion and neutralizing activity in mice.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

This study identifies molecular subtypes of prostate cancer using multi-omics data and clustering algorithms, revealing distinct clinical and biological features associated with each subtype.

This paper refines muscle-invasive bladder cancer classification using multi-omics data, identifying four subtypes with distinct prognoses and therapeutic responses.

A broadly neutralizing antibody protects against multiple SARS-CoV and SARS-CoV-2 variants in mice by targeting a conserved epitope in the receptor-binding domain.

This paper develops a deep learning system to assess upper airway obstruction and adenoid size in pediatric radiographs, achieving good segmentation performance and agreement with experts.