X. Wang

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

This study shows that Microsporidia infection impairs dendritic cell functions by targeting the p38/MAPK pathway via PP1, increasing susceptibility to secondary infections.

The study identifies ocean warming and nutrient availability as key drivers of equatorial marine extinctions during the Permian-Triassic mass extinction using geochemical and fossil data from the Meishan section.

This study uses single-cell RNA sequencing to identify cycling alpha cells as key beta cell progenitors in response to DYRK1A inhibitor treatment in human pancreatic islets.

This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

This study develops a mucosal nanoparticle flu vaccine using CRISPR-Cas to engineer bacteriophage T4, showing it induces both mucosal and systemic immunity in mice.

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

This study assesses PFAS levels in fish from Illinois waterways, finding elevated concentrations in specific areas and species, with implications for human health risks through fish consumption.

This paper introduces a method to enhance spatial resolution in lipid mass spectrometry imaging of mouse brain tissue by using a swellable polyelectrolyte gel, achieving subcellular-level visualization.

This study develops an efficient siRNA delivery system using extracellular vesicles, demonstrating effective gene silencing in vitro and tumor growth inhibition in vivo.

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

This study analyzes whole genomes of African bushpigs and Malagasy bushpigs, revealing recent divergence and gene flow, challenging species boundaries and linking their arrival in Madagascar to human migration.

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

This paper introduces tDKI to map cellular pathology in brain ischemia, showing it detects changes in cell morphology and membrane permeability in vivo.

The paper shows SwrA extends DegU binding over a UP element to activate flagellar gene expression in Bacillus subtilis, enabling motility and swarming.

This study identifies essential genes and genomic features of Xanthomonas citri using transposon mutagenesis, revealing insights into its genome organization and potential therapeutic targets.

The paper uses CRISPR/Cas9 screening in colorectal cancer organoids to identify novel metastasis regulators, finding Ctnna1 and Bcl2l13 as metastasis suppressors.

This study identifies PLK1 as a driver of an immunosuppressive tumor microenvironment in LUAD through single-cell RNA-seq and genetic models.

This paper models clathrin-mediated endocytosis to show that the switch between productive and abortive CCPs is an emergent property of clathrin-membrane interactions and EAPs.

This study shows macrophages form integrin-mediated adhesion rings to engulf surface-bound objects by local actin polymerization, not myosin II.

This study shows that PLK1 phosphorylates AHR in LUAD, promoting metastasis through DIO2-TH signaling.

This paper develops a CRISPR-Cas12a-based method for detecting Schistosoma japonicum circulating nucleic acids with high sensitivity and specificity, validated using rabbit serum samples.

This study simulates the feeding and respiration of early Cambrian cnidarian polyps using CFD to show how muscle contractions drive water flow, supporting hypotheses about ancestral medusozoan behavior.

The paper identifies TDIF ligand-activated PXY receptors and CAIL transcription factors as key to defining cambium stem cell identity in Arabidopsis roots and explains their positioning mechanism.

This paper analyzes the ecological diversity and evolution of Enantiornithes by introducing new data on Bohaiornithidae and integrating it with existing data on other enantiornithine families.

The paper reports cryo-EM structures of the Schizosaccharomyces pombe Clr6S complex, revealing its active site and interactions with a nucleosome.