X. Wang

This study shows that E2 protein interaction with BRD4's CTM and TopBP1 is essential for HPV16's mitotic chromatin association and plasmid segregation, offering therapeutic targets for viral genome targeting.

The paper examines latitudinal patterns in species aggregation and abundance, showing how these patterns affect coexistence in forests and introduces a framework to model their impact on extinction risk.

This study tracks human neural progenitor cell grafts in adult rats up to 9 months, revealing their migration and differentiation patterns, and highlights their potential for neural repair.

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

The paper identifies the Gabija complex's mechanism of sensing nucleotide depletion and executing DNA cleavage for antiviral defense, showing its unique synergy between GajA and GajB.

The paper identifies SREBF2 as a regulator of mregDC development and function in the tumor microenvironment, highlighting it as a therapeutic target for immune tolerance.

The paper designs, synthesizes, and characterizes a DNA nanorobot, NanoGripper, capable of capturing viral particles and functioning as a biosensor for SARS-CoV-2 detection in human saliva.

This study shows that targeting ACOD1 enhances the pro-inflammatory state and anti-tumor activity of human CAR-iMACs in solid tumors.

This study maps ex vivo terminal erythropoiesis from umbilical cord blood mononuclear cells and pluripotent stem cells, identifying differences in regulatory dynamics and CD99 expression affecting erythroid expansion and maturation.

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

This paper introduces DeepSEED, an AI framework for designing synthetic promoters by optimizing flanking sequences, showing improved performance in prokaryotic and eukaryotic systems.

This study shows that the COP9 signalosome promotes neointimal hyperplasia via deneddylation and CSN5-mediated nuclear export of p27 in vascular smooth muscle cells.

The paper uses computational methods to analyze mRNA sequences of bacterial type III and IV effectors, finding that type III effectors show high frameshift tolerance in secretion signals, while type IV show low tolerance.

The paper introduces MID, a deep learning method for high-content image analysis that outperforms existing tools in drug toxicity classification and compound identification.

This study uses high-throughput phenogenotyping to link Mtb genetic variants to clinical outcomes, identifying bacterial traits associated with treatment failure and transmission.

This study examines the substrate specificity and functional conservation of the SWEET10 transporter in pineapple by comparing it to Arabidopsis SWEET8 and analyzing its role in microspore formation.

This study identifies ginsentides as active compounds in ginseng that restore homeostasis under stress by interacting with multiple physiological systems.

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

This study shows that Staphylococcus aureus delta toxin promotes both extracellular membrane vesicle biogenesis and amyloid fibril formation in vitro, but amyloids are not detected in vivo despite MVs being present.

This study constructs a pan-cancer prognosis risk model using ADME genes under low press and hypoxia conditions, finding lower risk scores correlate with better survival in 25 cancer types.

The paper develops selective Aurora A-TPX2 inhibitors that show in vivo efficacy and synergy with paclitaxel in pancreatic cancer.

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

This paper uses a DNA flow-stretching assay to evaluate how a KCK tag affects DNA-binding protein behavior in single-molecule experiments.

This study uses single-cell transcriptome analysis to identify immune and metabolic mechanisms underlying coagulation abnormalities in SARS-CoV-2 infection.

The paper develops a nanoscale combination drug formulation targeting MERTK, FLT3, and BCL-2 to treat AML, showing improved synergistic responses in vitro and in patient samples.

This study identifies FAN, a homolog of AATF/Che-1 in Arabidopsis, as essential for genome stability through the ATR-induced DNA damage response pathway.

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

This study identifies Zbtb46 as a regulator that coordinates angiogenesis and immunity in tumors, with its downregulation promoting a pro-tumor microenvironment and its restoration improving tumor outcomes.