Y. Feng

This paper introduces BATTLES, a high-throughput method that applies biomechanical force to screen pMHCs for T-cell activation, revealing force- and sequence-dependent responses.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This paper presents a hardware-software solution for co-registering photoacoustic tomography and MRI images in vivo, demonstrating hybrid-contrast imaging of tumor microenvironments.

The paper develops a new assembly strategy to improve mitogenome reconstruction in plants, revealing mosaic structures and horizontal transfer contributions to mitochondrial evolution.

This study shows that gut microbiota in Anopheles stephensi affects tryptophan metabolism, with Pseudomonas alcaligenes reducing 3-HK to protect against Plasmodium infection.

The paper identifies paralogue-specific protein interactions of the MGCC module in the NuRD complex, revealing mechanisms for functional specificity and integration into other complexes.

This study identifies FAM72A as a regulator of mutagenic uracil repair during antibody maturation by antagonizing UNG2 activity.

The paper shows DNA demethylation of Foxp3 enhancer CNS2 switches transcriptional drivers to maintain Treg identity by stabilizing Foxp3 expression.

This study identifies INS1 as a protease critical for macrogamont formation and oocyst production in Cryptosporidium parvum, with loss of INS1 reducing virulence in mice.

This study shows RNF5 promotes AML growth by regulating RBBP4 and epigenetic pathways, and its inhibition enhances sensitivity to HDAC inhibitors, suggesting it as a therapeutic target and biomarker.

The paper introduces Deep-LUMEN, a deep learning algorithm for classifying lung epithelial spheroids from brightfield images, and validates its ability to detect morphological changes in response to drug treatments.

This paper proposes a gait-symmetry-based human-in-the-loop optimization method for unilateral transtibial amputees, improving gait symmetry and reducing metabolic cost.

This study develops TTA-UC-PLGA nanoparticles for in vivo cancer imaging and drug delivery, showing sustained UC signal detection in tumors 96 hours post-administration.

This study shows that eurycomanone promotes lipolysis and reduces fat accumulation by activating the cAMP/PKA pathway in 3T3-L1 cells and C57BL/6J mice.

This study evaluates three fecal immunoassay technologies for detecting canine Echinococcus infection in China, finding that sensitivity is lower than expected and further development is needed.

The paper analyzes canine cancer mutation rates across breeds and cancer types, finding a positive correlation with TP53 mutations and a breed-specific mutation signature in Golden Retrievers.

The paper introduces MRBLEs 2.0, a method for high-throughput synthesis of functionalized microspheres with spectral and magnetic encoding, demonstrating efficient conjugation of biomolecules and magnetic nanoparticle incorporation.

SIGAR infers germline genome architecture and rearrangements from short germline DNA reads without requiring a germline assembly, validated in ciliates with high accuracy.

This study clones, expresses, and evaluates the in vitro anticancer activity of Lp16-PSP, a protein from Lentinula edodes, showing selective cytotoxicity against HL-60 cells.

This study investigates the diversity anomaly of Heterotropa in insular versus continental regions by analyzing phylogenetic relationships and floral trait evolution.

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

This study compares clinical characteristics and prognosis of second primary non-small cell lung cancer after cervical cancer with first primary non-small cell lung cancer using SEER data.

This paper develops microbial strains for producing renewable fatty acid esters, achieving high yields and economic competitiveness in bioproduction.

This study investigates the co-production of tet(X6) and mcr-1 resistance genes on a single plasmid in E. coli, revealing their independent mechanisms of antibiotic resistance and the implications for antimicrobial resistance spread.

The paper shows dietary glucose promotes Plasmodium infection by expanding a gut bacterium that alkalizes mosquito midgut, enhancing parasite development.

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

This paper introduces A-Star, a method for detecting rare mutations with high sensitivity and multiplexing capability, achieving detection as low as 0.01% allele frequency.

This study links cellular virological stages in chronic hepatitis B to liver fibrosis progression through spatial and functional analysis of viral and host gene expression.

This study identifies RNF125's role in regulating HDAC2 and PDX1 to influence pancreatic cancer development and patient outcomes.